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  • The structures of single COOLAIR RNA isoforms change in abundance and shape in response to external conditions; structural mutation of these isoforms altered FLC expression and flowering time, consistent with a regulatory role of the COOLAIR structure in FLC transcription.

    • Minglei Yang
    • Pan Zhu
    • Yiliang Ding
    Article Open Access
  • Endocytosis and degradation of plasma membrane proteins in the axon initial segment, together with the diffusion-barrier mechanism, maintain a polarized distribution of plasma membrane proteins in Caenorhabditis elegans, mouse, rat and human neurons.

    • Kelsie Eichel
    • Takeshi Uenaka
    • Kang Shen
    Article Open Access
  • Multidimensional time- and angle-resolved photoelectron spectroscopy is used to determine the interlayer exciton formation process, reveal a direct hallmark of the superlattice moiré modification, and reconstruct the real-space wavefunction distribution.

    • David Schmitt
    • Jan Philipp Bange
    • Stefan Mathias
  • CD62L+ precursors of exhausted T cells retain long-term proliferative potential, multipotency and repopulation capacity, and the transcription factor MYB is essential for the development and function of this population of cells.

    • Carlson Tsui
    • Lorenz Kretschmer
    • Axel Kallies
    Article Open Access
  • A mechanism for self-oscillating pumping in a quantum gas is demonstrated using a Bose–Einstein condensate coupled to a dissipative cavity, where a particle current is observed without external periodic driving.

    • Davide Dreon
    • Alexander Baumgärtner
    • Tobias Donner
  • Live-seq, a single-cell transcriptome profiling approach that preserves cell viability during RNA extraction using fluidic force microscopy, can address a range of biological questions by transforming scRNA-seq from an end-point to a temporal analysis approach.

    • Wanze Chen
    • Orane Guillaume-Gentil
    • Bart Deplancke
    Article Open Access
  • A dynamic optimization approach using plant species data from 458 forest ecoregions suggests a strategy for when and where to conserve forests globally over the next 50 years to maximize the conservation of plant biodiversity.

    • Ian H. Luby
    • Steve J. Miller
    • Stephen Polasky
  • Spatial-ATAC-seq—spatially resolved chromatin accessibility profiling of tissue sections using next-generation sequencing—delineated tissue-region-specific epigenetic landscapes in mouse embryos and identified gene regulators involved in the development of the central nervous system and the lymphoid tissue.

    • Yanxiang Deng
    • Marek Bartosovic
    • Rong Fan
    Article Open Access
  • This work introduces lightweight, leaf-like photoelectrochemical devices for unassisted water splitting and syngas production, which could be used in the fabrication of floating systems for solar fuel production.

    • Virgil Andrei
    • Geani M. Ucoski
    • Erwin Reisner
  •  Malignant evolution enabled by p53 inactivation in mice proceeds through an ordered and predictable pattern of Trp53 loss of heterozygosity, accumulation of deletions, genome doubling and the emergence of gains and amplifications.

    • Timour Baslan
    • John P. Morris IV
    • Scott W. Lowe
    Article Open Access
  • A compute-in-memory neural-network inference accelerator based on resistive random-access memory simultaneously improves energy efficiency, flexibility and accuracy compared with existing hardware by co-optimizing across all hierarchies of the design.

    • Weier Wan
    • Rajkumar Kubendran
    • Gert Cauwenberghs
    Article Open Access
  • Rabi dynamics between the ground state and an excited state in helium atoms are generated using femtosecond extreme-ultraviolet pulses from a seeded free-electron laser, which may allow ultrafast manipulation of coherent processes at short wavelengths.

    • Saikat Nandi
    • Edvin Olofsson
    • Jan Marcus Dahlström
    Article Open Access