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Quinuclidine-pyridone and sulfonamide-pyridone ligands enable transannular γ-methylene C–H arylation of cycloalkane carboxylic acids with a range of ring sizes, bringing us closer to molecular editing of saturated carbocycles.
We model occult preneoplasia by biallelic inactivation of TP53, a common early event in gastric cancer, in human gastric organoids, the results implying predictability in the earliest stages of tumorigenesis.
Detailed atomic models of axonemes from algal flagella and human respiratory cilia, which are hair-like protrusions from cells that enable motility and clear mucus from human airways, could provide insights into how they function.
The cycles of laser light have been used to advance transmission electron microscopy to attosecond time resolution, revealing the interactions between light and matter in terms of their fundamental dimensions in space and time.
A computational model based on a heuristic value function and forward search algorithm predicts human choices, response times and eye movements in games of games of four-in-a-row, and shows evidence for increased planning and improved attention with increased expertise.
Reconstruction of oceanic phosphorus concentrations during a large negative carbon-isotope excursion co-occurring with global oceanic oxygenation and evolution of some of Earth’s earliest animals suggests that decoupled phosphorus and ocean anoxia cycles during the Ediacaran may have prolonged the rise of atmospheric oxygen.
Records show that tropical water availability rather than temperature appears to have been increasingly controlling the interannual variability of the terrestrial carbon cycle over the past 59 years.
