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Point-of-care (POC) diagnostics are particularly important in resource-limited settings. To ensure their sustainability, deployment and uptake by underserved communities, systemic, infrastructural, operational and logistical limitations need to be addressed.
An article in Science reports a co-polymer with both semiconducting and adhesive properties, which can effectively stick an organic electrochemical transistor (OECT)-based sensor to living tissues.
An article in Nature Communications reports that substitution of animal-based food by plant-based alternatives greatly reduces agricultural input use, greenhouse gas emissions and biodiversity loss.
An article from Nature Biomedical Engineering reports the development of an infrared light-emitting cancer nanovaccine and two other nanoprobes for tracking the vaccine and the associated immune response.
To address inappropriate behaviour in the scientific community and nurture a culture of accountability, individuals must be empowered to speak up. Guidance on preventing and handling inappropriate behaviour at conferences, using case studies and checklists, to build a community that thrives on respect and inclusivity is presented.
An article in Science Robotics reports a soft robotic drug-delivery device that can sense and respond to the formation of scar tissue in real time to maintain its ability to deliver drugs long-term.
At the LV Prasad Eye Institute in India, we developed an ophthalmic electronic medical record and hospital management system, integrating clinical, surgical and operational functions in one platform to allow digital eye care services at the point of care.
The US Food and Drug Administration’s internal database of 510(k)-cleared medical devices was searched for additively manufactured devices cleared between 2010 and 2020. The information and analysis provided will assist the medical device community to further understand the application of additive manufacturing to regulated devices.
Bioengineers need to adopt holistic and human-centred design principles in the development of technologies intended for applications in low-resource settings, to overcome infrastructural limitations and ensure functionality in all environments.
Silk protein can be applied as an edible food coating to extend the shelf life of food products by slowing dehydration and reducing oxidative stresses. Here, we highlight the commercialization of Mori Silk, from lab discovery and first proof of concept to manufacturing, scale-up, field validation, regulatory approval and forward-looking challenges.
The potential of tissue engineering to deliver clinical advances hinges on a connected ecosystem that includes academics, funding agencies, entrepreneurs, investors, the pharmaceutical industry and regulatory bodies. Open dialog on goals and risks across these stakeholders is key to implementing bioengineered tissue models in drug development and tissue therapies.
Radiotheranostics combines disease-specific molecular imaging and radionuclide therapy. We present new and promising targets, tracers and isotopes for radiotheranostics and outline the road to clinical translation of the 177Lu–LNC1004 radiopharmaceutical, which has recently been approved by the US Food and Drug Administration (FDA) for a phase I clinical trial.
An article in Nature Communications reports a metamaterial-based textile that can be worn as clothing to enable direct implant-to-implant wireless networking at the scale of the human body.
Human-based in vitro models, such as organoids and organs-on-chips, may have the potential to replace certain animal models in preclinical research. But how much ‘human’ is needed in these models?
An article in Nature reports a multidimensional question-answering clinical benchmark, evaluating the clinical knowledge of fine-tuned variants of PaLM, a 540-billion parameter, densely activated large language model.
Leveraging the underlying mechanism of phase-separating biomolecular condensates could prove a great asset for developing designer condensates in bioengineering applications.
An article in Science Advances reports a minimally invasive approach for continuous glucose monitoring using biodegradable microneedles connected to a smartphone app for diabetes tracking.
Women’s health has long been overlooked in both fundamental and clinical research, which, sadly, also holds true for the bioengineering field — albeit things are slowly changing.
