Metabolizing alcohol via ALDH2 in cerebellar astrocytes

  • Shiyun Jin
  • Qi Cao
  • Li Zhang


  • Originally scheduled for publication in time for the 2020 Summer Olympic Games, we bring you a special focus on exercise metabolism and health, consisting of Reviews and Commentary revisiting foundational topics and highlighting new paradigms in exercise and muscle metabolism, as well as their broader implications for organismal health.

  • The Career Pathways series features the stories of Nature Metabolism authors and their self-professed journeys to publication as young investigators. This Collection brings together the Career Pathway pieces and the original research published in Nature Metabolism by the authors.

  • Along with Nature Cell Biology and Nature Reviews Molecular Cell Biology, Nature Metabolism is proud to present an exciting virtual conference in June 2021 with a broad focus on metabolic underpinnings of common pathologies such as cardiovascular disease, obesity, and cancer.

Nature Metabolism is a Transformative Journal; authors can publish using the traditional publishing route OR via immediate gold Open Access.

Our Open Access option complies with funder and institutional requirements.


  • The COVID-19 pandemic has stretched healthcare resources and caused severe knock-on effects on patients with metabolic diseases worldwide. We encourage clinicians and patient-interest groups in the field of diabetes and metabolism to raise their voices to ensure adequate care and admission of patients.

    • Stefan R. Bornstein
    • Francesco Rubino
    • Geltrude Mingrone
  • On the second anniversary of Nature Metabolism, we reflect on some of the developments at the journal against the backdrop of this extraordinary year.

  • The prevalence of COVID-19-associated diabetes is not the result of a single event but of a combination of disease susceptibility associated with chronic illness and COVID-19-specific mechanisms affecting metabolism. Whether a separate entity of post-COVID-19 diabetes, possibly associated with lasting β-cell damage, also exists is not yet clear.

    • Domenico Accili
  • Cell culture media are typically selected on the basis of common laboratory practices but have major effects on the validity, reproducibility and physiological relevance of the scientific findings. We provide arguments and quantitative examples of why choosing an appropriate cell culture medium matters, particularly in metabolic studies.

    • Shoval Lagziel
    • Eyal Gottlieb
    • Tomer Shlomi
  • As the world came to a standstill in the spring of 2020, so did the work on our Focus issue on exercise metabolism and health, which was originally scheduled for publication to coincide with the 2020 Summer Olympic Games.