Articles in 2020

Developing swarm robots for a specific application is a time consuming process and can be alleviated by automated optimization of the behaviour. Birattari and colleagues discuss that there are two fundamentally different design approaches; a semi-autonomous one, which allows for situation specific tuning from human engineers and one that needs to be entirely autonomous.

The role of DNA methylation on N⁶-adenine (6mA) in eukaryotes is a challenging research problem. Tan et al. develop a deep-learning-based algorithm to predict 6mA sites from sequences at single-nucleotide resolution, and apply the method to three representative model organisms. The method is further developed to visualize regulatory patterns around 6mA sites.

This review covers the history of procedural content generation (PCG) approaches for video games, and how these approaches are now used to generate training data and environments for machine learning models. The authors then discuss how PCG may be crucial for training agents which generalise well.

There is a need to consider how AI developers can be practically assisted in identifying and addressing ethical issues. In this Comment, a group of AI engineers, ethicists and social scientists suggest embedding ethicists into the development team as one way of improving the consideration of ethical issues during AI development.

As robot swarms move from the laboratory to real-world applications, a routine checklist of questions could help ensure their safe operation.

Gene expression is regulated by a variety of mechanisms, which have been difficult to study in a unified way. The authors propose a flexible framework that can integrate different types of data for studying their joint effects on gene expression. The framework uses a general network representation for data integration, metapaths for inputting prior knowledge of gene regulatory mechanisms, and embedding techniques for capturing complex structures in the data.

Robot-assisted microsurgery promises high stability and accuracy for instance in eye- or neurosurgery applications. A new miniature robotics device, based on an origami-inspired design, can make complex 3D motions and reaches a precision of around 26 micrometres.

AI tools used in society often enhance inequality, affecting Black lives disproportionally. Addressing this issue will require more than technological solutions. Researchers and experts in the field are overwhelmingly white and need to engage and listen to those experiencing the harm.

An important task in system biology is to understand cellular processes through the lens of gene sets and their expression patterns. Machine learning can help, but genes form complex interaction networks, and levarging this information in machine learning applications requires a sophisticated data representation.

Machine learning has become popular in solving complex optical problems such as recovering the input phase and amplitude for a specific pattern or image measured through a scattering medium. In a more challenging application, Rahmani et al. consider the problem of also producing desired outputs for such a nonlinear system when only some intensity-only measurements of example outputs are available. They develop a neural network approach that can ensure the transmission of images through a highly nonlinear system—a multimode fibre—with a 90% fidelity.

Machine learning models are commonly used to predict risks and outcomes in biomedical research. But healthcare often requires information about cause–effect relations and alternative scenarios, that is, counterfactuals. Prosperi et al. discuss the importance of interventional and counterfactual models, as opposed to purely predictive models, in the context of precision medicine.

Deep learning methods can be a powerful part of digital pathology workflows, provided well-annotated training datasets are available. Tolkach and colleagues develop a deep learning model to recognize and grade prostate cancer, based on a convolution neural network and a dataset with high-quality labels at gland-level precision.

Currently available quantum hardware is limited by noise, so practical implementations often involve a combination with classical approaches. Sels et al. identify a promising application for such a quantum–classic hybrid approach, namely inferring molecular structure from NMR spectra, by employing a range of machine learning tools in combination with a quantum simulator.

A goal of biology is to identify the molecular mechanisms that control differential gene expression. Tasaki et al. have developed a framework that integrates genomic data into a deep learning model of transcriptome regulations to predict multiple transcriptional effects in tissue- and person-specific transcriptomes.

Artificial intelligence tools can help save lives in a pandemic. However, the need to implement technological solutions rapidly raises challenging ethical issues. We need new approaches for ethics with urgency, to ensure AI can be safely and beneficially used in the COVID-19 response and beyond.

Expectations are high for AI to help fight COVID-19. But before AI tools can make an impact, global collaboration and high-quality data and model sharing are needed.

Contact-tracing apps could help keep countries open before a vaccine is available. But do we have a sufficient understanding of their efficacy, and can we balance protecting public health with safeguarding civil rights? We interviewed five experts, with backgrounds in digital health ethics, internet law and social sciences.

China’s New Generation Artificial Intelligence Development Plan was launched in 2017 and lays out an ambitious strategy, which intends to make China one of the world’s premier AI innovation centre by 2030. This Perspective presents the view from a group of Chinese AI experts from academia and industry about the origins of the plan, the motivations and main focus for attention from research and industry.