Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Computational approaches for drug repurposing can accelerate the identification of treatments during a pandemic. In this Review, the authors discuss this topic in the context of COVID-19 and propose a strategy to make computational drug repurposing more effective in future pandemics.
While estimating causality from observational data is challenging, quasi-experiments provide causal inference methods with plausible assumptions that can be practical to a range of real-world problems.