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Volume 1 Issue 6, June 2020

Volume 1 Issue 6

Linking EMT and the microbiome to colorectal cancer development

Epithelial–mesenchymal transition synergizes with the intestinal microbiome to boost the development of colorectal cancer.

See Slowicka et al.

Image: David Nittner, VIB-KU Leuven. Cover Design: Allen Beattie.

Editorial

  • Editorial |

    Inequalities are prevalent across the spectrum of cancer research and patient care, with destructive repercussions for people and society. We cannot ignore them and must act against the social injustices that perpetuate them.

Comment & Opinion

  • Comment |

    The COVID-19 pandemic has disrupted the spectrum of cancer care, including delaying diagnoses and treatment and halting clinical trials. In response, healthcare systems are rapidly reorganizing cancer services to ensure that patients continue to receive essential care while minimizing exposure to SARS-CoV-2 infection.

    • Mike Richards
    • Michael Anderson
    • Elias Mossialos
  • Comment |

    The risks posed to patients with cancer by the current COVID-19 pandemic demand rapid structural changes in healthcare delivery, with many positive changes likely to continue long term. An immediate critical reassessment of trial methodology based on clinical and scientific priorities is essential to ensure the resilience of clinical cancer research and optimize patient-centered care.

    • Gary J. Doherty
    • Mehmet Goksu
    • Bruno H. R. de Paula

News & Views

  • News & Views |

    KEAP1 is a tumor suppressor encoded by a gene commonly mutated in lung cancer. A systematic search for Keap1-mutant cancer vulnerabilities now reveals that Slc33a1 is a context-specific essential gene that represents a promising new anti-cancer target.

    • Luke A. Gilbert
  • News & Views |

    The pre-metastatic niche is a complex microenvironment formed by the influence of tumor-derived factors on stromal and immune cells at distant sites of disseminated tumor-cell colonization. Signaling through the kinase p38α and regulation of the type I interferon receptor are now linked to formation of the pre-metastatic niche.

    • Sabina Kaczanowska
    • Rosandra N. Kaplan

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