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Dive and colleagues develop an approach for genome-wide cell-free DNA methylation profiling, which can sensitively detect small cell lung cancer in liquid biopsy of patient samples, including stage I disease and molecularly defined SCLC subtypes.
Danko and colleagues develop BayesPrism, a bulk RNA sequencing deconvolution tool to infer cell type composition and cell-specific expression levels across clinical cancer datasets.
Tamborero and colleagues develop the Molecular Tumor Board Portal, a virtual platform that integrates and interprets genomics and clinical data from prospective clinical studies, to support clinical decision-making for precision oncology.
Bodenmiller and colleagues present a method for three-dimensional analysis of tissue architecture using imaging mass cytometry and demonstrate the utility in resolving cellular interactions in the tumor microenvironment, in human breast cancer samples.
Van Allen and colleagues develop a data-integration framework with an underlying knowledge base supporting clinical decision making and also serving as a hypothesis-generating platform, which the authors benchmark and validate across several retrospective cohorts and a prospective precision oncology trial.
Wu and colleagues develop a barcoding tool, ClonMapper, which permits single-cell lineage tracing and clonal isolation and demonstrate its utility to study clonal dynamics in human CLL cells in the context of chemotherapy treatment and resistance.
Poirier and colleagues have developed a system for in vivo genome editing of patient-derived xenografts using inducible CRISPR-Cas9 and demonstrate applications for modeling gene dependencies and drug resistance.
