Volume 5 Issue 7, July 2021

Sensing deep-tissue physiology via wearable ultrasonic phased arrays

This issue highlights diagnostic assays and diagnostic devices for the detection of nucleic acids in saliva or other biofluids or of cancer biomarkers in blood, and portable or wearable diagnostic devices designed for the detection or monitoring of a variety of physiological signals.

The cover illustrates a prototype ultrasonic phased array for the monitoring of blood flows in deep tissues.

See Wang et al.

Image: Sheng Xu, University of California San Diego. Cover Design: Erin Dewalt.

Editorial

Undeterred by the risk of failure

The proposal for an Advanced Research Projects Agency for Health (ARPA-H) being considered by the United States Congress is bold and necessary, yet will require unrelenting focus, independence and a measured risk-taking culture.

Editorial 16 Jul 2021

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News & Views

Antigen sensing via nanobody-coated transistors

Organic electrochemical transistors functionalized with antigen-specific nanobodies can rapidly and specifically detect antigens at attomolar-to-nanomolar levels in bodily fluids.

Howard E. Katz

Collection:

Bioelectronic devices
News & Views 16 Jul 2021
Wearable sensors of the elasticity of deeper skin

The elastic modulus of the superficial and deep layers of the skin can be dynamically measured via wearable conformal electromagnetic devices consisting of a vibratory actuator and a soft strain-sensing sheet.

Levent Beker

Collection:

Bioelectronic devices
News & Views 16 Jul 2021

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Reviews

CRISPR-based diagnostics

This Review summarizes the rapidly expanding toolbox of assays for CRISPR-based diagnostics and highlights their point-of-care applications.

Michael M. Kaminski
Omar O. Abudayyeh
James J. Collins

Collection:

Technology for diagnostics
Review Article 16 Jul 2021

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Research

Massively scaled-up testing for SARS-CoV-2 RNA via next-generation sequencing of pooled and barcoded nasal and saliva samples

Next-generation sequencing of pooled samples tagged with sample-specific molecular barcodes enables the testing, for SARS-CoV-2 RNA, of thousands of nasal or saliva samples in a single run without the need for RNA extraction.

Joshua S. Bloom
Laila Sathe
Valerie A. Arboleda

Collection:

Technology for diagnostics
Article 01 Jul 2021
Rapid single-molecule detection of COVID-19 and MERS antigens via nanobody-functionalized organic electrochemical transistors

Organic electrochemical transistors functionalized with antigen-specific nanobodies can rapidly detect attomolar-to-nanomolar levels of the antigens in complex bodily fluids.

Keying Guo
Shofarul Wustoni
Sahika Inal

Collection:

Technology for diagnostics
Article 24 May 2021
An integrated magneto-electrochemical device for the rapid profiling of tumour extracellular vesicles from blood plasma

A device that integrates the enrichment and electrochemical detection, in less than one hour, of tumour extracellular vesicles bearing clinically relevant tumour biomarkers accurately classifies patients with colorectal cancer.

Jongmin Park
Jun Seok Park
Hakho Lee

Collections:

Technology for diagnostics

Extracellular vesicles
Article 28 Jun 2021
Selective multiplexed enrichment for the detection and quantitation of low-fraction DNA variants via low-depth sequencing

Low-frequency DNA variants can be detected via low-depth multiplexed sequencing after their amplification using polymerase chain reaction and rationally designed ‘blocker’ oligonucleotides.

Ping Song
Sherry X. Chen
David Yu Zhang

Collection:

Cancer diagnostics
Article 03 May 2021
Highly multiplexed rapid DNA detection with single-nucleotide specificity via convective PCR in a portable device

A portable PCR assay performed in a toroidal convection chamber housing an array of fluorescently quenched oligonucleotide probes allows for the rapid quantification of multiple DNA targets with single-nucleotide discrimination.

Dmitriy Khodakov
Jiaming Li
David Yu Zhang
Article 01 Jul 2021
Discrimination of single-point mutations in unamplified genomic DNA via Cas9 immobilized on a graphene field-effect transistor

Liquid-gated graphene field-effect transistors anchoring guide RNA–Cas9 complexes can be used to discriminate between single-point mutations in human genomic samples.

Sarah Balderston
Jeffrey J. Taulbee
Kiana Aran

Collection:

Technology for diagnostics
Article 05 Apr 2021
Contactless optical coherence tomography of the eyes of freestanding individuals with a robotic scanner

A robot-mounted scanner enables optical coherence tomography, at safe distances, of the eyes of freestanding individuals without operator intervention or head stabilization.

Mark Draelos
Pablo Ortiz
Joseph A. Izatt

Collection:

Technology for diagnostics
Article 12 Jul 2021
An epidermal patch for the simultaneous monitoring of haemodynamic and metabolic biomarkers

A skin-worn device that simultaneously monitors blood pressure and heart rate via ultrasonic transducers and multiple biomarkers via electrochemical sensors captures physiological effects of food intake and exercise in human volunteers.

Juliane R. Sempionatto
Muyang Lin
Joseph Wang

Collection:

Bioelectronic devices
Article 15 Feb 2021
Continuous monitoring of deep-tissue haemodynamics with stretchable ultrasonic phased arrays

A prototype skin-conformal ultrasonic phased array enables the monitoring of physiological signals from deep tissues, as shown for the measurements of cardiac Doppler waveforms and central and cerebral blood flows.

Chonghe Wang
Baiyan Qi
Sheng Xu

Collections:

Bioelectronic devices

Technology for diagnostics
Article 16 Jul 2021
Miniaturized electromechanical devices for the characterization of the biomechanics of deep tissue

Electromagnetic devices involving a vibratory actuator and a soft strain-sensing sheet can dynamically measure the Young’s modulus of skin and of other soft biological tissues at depths of millimetres.

Enming Song
Zhaoqian Xie
John A. Rogers

Collection:

Bioelectronic devices
Article 27 May 2021
A soft and transparent contact lens for the wireless quantitative monitoring of intraocular pressure

A soft and transparent contact lens can be used to wirelessly monitor intraocular pressure quantitatively in humans.

Joohee Kim
Jihun Park
Jang-Ung Park

Collection:

Bioelectronic devices
Article 03 May 2021

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Volume 5 Issue 7, July 2021

Sensing deep-tissue physiology via wearable ultrasonic phased arrays

Editorial

Undeterred by the risk of failure

News & Views

Antigen sensing via nanobody-coated transistors

Wearable sensors of the elasticity of deeper skin

Reviews

CRISPR-based diagnostics

Research

Massively scaled-up testing for SARS-CoV-2 RNA via next-generation sequencing of pooled and barcoded nasal and saliva samples

Rapid single-molecule detection of COVID-19 and MERS antigens via nanobody-functionalized organic electrochemical transistors

An integrated magneto-electrochemical device for the rapid profiling of tumour extracellular vesicles from blood plasma

Selective multiplexed enrichment for the detection and quantitation of low-fraction DNA variants via low-depth sequencing

Highly multiplexed rapid DNA detection with single-nucleotide specificity via convective PCR in a portable device

Discrimination of single-point mutations in unamplified genomic DNA via Cas9 immobilized on a graphene field-effect transistor

Contactless optical coherence tomography of the eyes of freestanding individuals with a robotic scanner

An epidermal patch for the simultaneous monitoring of haemodynamic and metabolic biomarkers

Continuous monitoring of deep-tissue haemodynamics with stretchable ultrasonic phased arrays

Miniaturized electromechanical devices for the characterization of the biomechanics of deep tissue

A soft and transparent contact lens for the wireless quantitative monitoring of intraocular pressure

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