Volume 1 Issue 7, July 2017

Genetically modified bacteria provide a long-lasting record of intestinal inflammation in mice.

Long single-stranded DNA probes enable the capture and multiplexed cloning of DNA at the megabase scale.

Microscale arrays of protein–polysaccharide clusters enable the functional characterization of human-neutrophil migration.

A light-sheet microscope offers fast three-dimensional imaging of intact clinical tissue samples over large fields of view.

Cellular biophysical features are identified as predictive biomarkers of ageing.

A light-sheet microscope images large surgical and biopsy specimens non-destructively over large fields of view in two and three dimensions, with the same level of detail as traditional slide-based histopathology.

A library of single-strand oligonucleotide probes with a common long-adapter sequence can clone, in a single reaction, thousands of open reading frames spanning 400–5,000 bp, and has been applied to DNA from human stool and microbiome samples.

Large microscale arrays of zymosan particle clusters enable the characterization of human-neutrophil swarming, including the presence of start and stop signals, and the deficient swarming behaviour of neutrophils from patients following major trauma.

The biophysical properties of cells can be used to predict the cellular age of humans with higher accuracy than conventional biomolecular markers.

An array-based method can identify synthetic hydrogels that outperform Matrigel in screening for vascular-disruptor compounds and in supporting the expansion and pluripotency of human embryonic stem cells.