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Analyses of interregional neural networks from electrocorticography data from a large database of individuals with medication-resistant epilepsy highlight the structural, geometric and genetic factors that shape network organization.
The efficiency of delivery of anticancer drugs by microparticles derived from tumour-repopulating cells isolated from 3D fibrin gels is enhanced by the microparticles’ softness.
A method that combines a depth-sensing camera and machine learning can track the movements of up to four mice in real time and for several days, extracting both individual and group behavioural traits.
A microfluidic intestine-on-a-chip that allows the control of physiologically relevant oxygen gradients, enables the extended coculture of living human intestinal epithelium with stable communities of aerobic and anaerobic human gut microbiota.
A microfluidic assay predicts the metastatic potential of breast cancer specimens by quantifying the abundance and proliferative index of the migratory cells within them.
An analysis of a proteomics database of leukaemia cell lines and samples from patients with acute myelogenous leukaemia uncovers heterogeneity in protein expression as well as proteomic hallmarks and signatures for patient stratification.
A viscoelastic adhesive patch that accommodates the myocardium’s cyclic deformation outperforms most existing acellular epicardial patches in reversing left ventricular remodelling and in restoring heart function after myocardial infarction in rats.
A thermogelling polymer that acts as an internal tamponade can repair detached retinas and trigger the formation of a vitreous-like body, as shown in retinal-detachment rabbit and non-human-primate models.
A quantitative microimmunohistochemistry assay based on the evolution of immunohistochemistry signals during tissue staining enhances the stratification of tumour samples.
A comparison of the molecular, cellular and functional characteristics of three congruent patient-specific cell types for the modelling of Charcot−Marie−Tooth 1A reveals commonly upregulated chemokines.
A nanomedicine encapsulating a docetaxel prodrug, and conjugated to an antibody specific for the receptor EphA2, provides enhanced antitumour activity in multiple tumour-xenografted mice, and has minimal toxicity in rats and dogs.
A dual positron emission tomography–near-infrared probe enables the visualization of the early trafficking dynamics of an injected model mRNA vaccine in non-human primates.
A suite of glass pipettes with integrated microelectrodes that simultaneously acquire intracellular and extracellular data in living mice and rats yield ground-truth data for validation of the performance of spike-sorting algorithms.
Single-cell photoacoustic microscopy can perform high-throughput measurements of intratumoral metabolic heterogeneity in specimens from patients with breast cancer.
Optoacoustic neuroimaging of mice expressing a genetically encoded calcium indicator allows for rapid, high-resolution, whole-brain 3D snapshots of neuronal calcium activity and haemodynamics.
An electrical biosensor combining CRISPR–Cas9 and a graphene field-effect transistor detects target genes in purified genomic samples at high sensitivity, within 15 minutes, and without the need for amplification.
The physiological degradation of programmed-death ligand 1 is reduced by the palmitoylation of its intracellular domain, and this process can be inhibited to promote T-cell immunity against tumours.
A tumour-on-a-chip model featuring patient-derived glioblastoma cells, vascular endothelial cells and decellularized extracellular matrix from brain tissue can be used to identify patient-specific resistance to standard chemoradiotherapy.
A microphysiological model of the bronchial airways enables the study of the mechanochemical feedback interactions between smooth muscle cells and epithelial cells that underlie bronchospasm.