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Masking interleukin-12 with a domain of the interleukin-12 receptor via a linker cleavable by tumour-associated proteases eliminates systemic immune-related adverse events and triggers potent therapeutic effects in mice bearing immunologically cold tumours.
Tumour vaccines consisting of outer membrane vesicles bearing a specific tumour antigen and produced in the intestine by ingested genetically engineered bacteria generate long-term antitumour immunity in mice.
The metabolically driven maturation of geometrically aligned human cardiac microtissues on a microfabricated chip reduces cell-phenotype-dependent variabilities in the action-potential morphology and calcium handling of the cardiomyocytes.
Tissue chips with matured human heart, liver, bone and skin tissue niches linked by recirculating vascular flow recapitulate interdependent functions of these organs.
Tissues and organoids derived from human pluripotent stem cells with knocked-out kinesin-2 subunits lack cilia, and can be used to model ciliopathy phenotypes and to reveal underlying mechanisms of disease.
The carryover of mitochondrial DNA in mitochondrial replacement therapy can be reduced via forced mitophagy by pre-labelling the mitochondrial outer membrane of a donor zygote with an autophagy receptor, as shown in mouse and human embryos.
Prospective testing of a clinical fiberscope with a lightproof enclosure for Cerenkov luminescence imaging using five different radiotracers showed satisfactory agreement with standard-of-care nuclear imaging for tumour location.
A strain of Lactococcus lactis engineered to altruistically degrade β-lactam antibiotics through the secretion and extracellular assembly of a heterodimeric β-lactamase prevented dysbiosis in the gut of mice treated with ampicillin.
The T-cell receptors of tumour-antigen-specific T cells can be rapidly detected and cloned by a system leveraging the activation of T cells via cis interactions.
A cost-aware AI framework facilitates the development of predictive AI models that optimize the trade-off between prediction performance and feature cost.
T cells expressing a pluripotent pro-inflammatory neutrophil-activating protein from Helicobacter pylori trigger endogenous bystander T-cell responses against solid cancers.
Multiple radionuclides can be simultaneously visualized in vivo by an imaging system providing high-resolution spectra that are then fitted to an X-ray analysis model of the emission lines of the radionuclides in the chosen energy band.
Cardiovascular progenitor cells that self-renew in chemically defined and xeno-free conditions and that preserve their cardiovascular differentiation capacity in vitro and in vivo can be derived from fibroblasts via a cocktail of six small molecules.
Selective activation of the hepatoportal nerve plexus via peripheral focused ultrasound stimulation improves glucose homoeostasis and enhances glucose tolerance and utilization in rodent models of diabetes and in swine.
An endovascular wireless and battery-free millimetric implant enables the stimulation of peripheral nerves that are difficult to reach via traditional surgeries.
Deep-learning models trained on external eye photographs can detect diabetic retinopathy, diabetic macular oedema and poor blood glucose control more accurately than models relying on demographic and medical history data.
HIV proviruses and their adjacent host DNA junctions can be assembled via high-throughput droplet-based whole-genome amplification followed by a polymerase chain reaction to tag droplets containing proviruses for sequencing.
Benchtop and miniaturized microscopes leveraging single-objective light-sheet illumination allow for volumetric histological imaging of living tissue, in real time and without the need for tissue staining or excision.
A protocol for the production of human spinal-cord-like organoids that recapitulate the tube-forming morphogenesis of the early human spinal cord facilitates screening for antiepileptic drugs that can cause neural-tube defects.
Patterned organoids and bioprinted tissues can be generated by simultaneously co-differentiating pluripotent stem cells into distinct cell types via the forced overexpression of transcription factors, independently of culture-media composition.