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Constitutive absence of the network driver TYROBP in an amyloidosis mouse model prevented appearance of clinical phenotype despite unchanged amyloid deposits and decreased microglia clustering around amyloid plaques. Images of 6E10-immunoreactive plaques (red) and Iba1-immunostained microglia (green) in prefrontal cortices of APP/PSEN1 (upper panel) and APP/PSEN1;Tyrobp(-/-) (lower panel) mice. For more information see the article by Haure-Mirande et al. on pages 431-446.