Volume 17 Issue 2, February 2012

Genes associated with autism spectrum disorders (ASD) are coordinately expressed in human neurons during the differentiation process. In this image, normal human neural progenitors have been differentiated for four weeks into postmitotic neurons. Red staining indicates Tuj1-positive neurons, green staining demarcates nestin-positive progenitors, and blue staining marks nuclei. Superimposed on the cells is an example of a network containing an enrichment of ASD genes. The most highly connected genes are depicted by large blue circles. Gene names have been removed for clarity. For more info on this topic, please refer to the article by Konopka et al. on pages 202–214.