Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
A challenge in translational research is comparing behaviors across species. A new study combines a novel behavioral paradigm in rats and humans with reinforcement learning to infer shared computations for goal-directed navigation.
The application of genome-editing tools to generate point mutations in animal models is of particular value for precise disease modeling, but the PAM requirement of Cas enzymes is a critical limiting factor. Two new studies demonstrate that SpRY variant displays efficient genome editing in a nearly PAM-less manner in zebrafish, expanding the targeting scope of base editors in this model.
Single nucleotide polymorphisms in the FKBP5 gene influence the risk of developing stress-related disorders, but the underlying processes are not fully understood. Animal models offer a possibility to investigate the influence of FKBP5 gene variants on the stress response system.
New insights into gut-brain axis and cognition function show that accumulation of Caudovirales bacteriophages in the gut microbiota is associated with improved executive function and memory.