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Predicting birth weight in fetuses with gastroschisis

Journal of Perinatology volume 38, pages 122–126 (2018)Cite this article

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Abstract

Objective:

To determine the accuracy of commonly utilized ultrasound formulas for estimating birth weight (BW) in fetuses with gastroschisis.

Study Design:

A retrospective review was conducted of all inborn pregnancies with gastroschisis within the five institutions of the University of California Fetal Consortium (UCfC) between 2007 and 2012. Infants delivered at ⩾28 weeks who had an ultrasound within 21 days before delivery were included. Prediction of BW was evaluated for each of the five ultrasound formulas: Hadlock 1 (abdominal circumference (AC), biparietal diameter (BPD), femur length (FL) and head circumference (HC)) and Hadlock 2 (AC, BPD and FL), Shepard (AC and BPD), Honarvar (FL) and Siemer (BPD, occipitofrontal diameter (OFD), and FL) using Pearson’s correlation, mean difference and percent error and Bland–Altman analysis. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for the ultrasound diagnosis of intrauterine growth restriction (IUGR) were assessed.

Results:

We identified 191 neonates born with gastroschisis within the UCfC, with 111 neonates meeting the inclusion criteria. The mean gestational age at delivery was 36.3±1.7 weeks and the mean BW was 2448±460 g. Hadlock (1) formula was found to have the best correlation (r=0.81), the lowest mean difference (8±306 g) and the lowest mean percent error (1.4±13%). The Honarvar and Siemer formulas performed significantly worse when compared with Hadlock 1, with a 13.7% (P<0.001) and 3.9% (P=0.03) difference, respectively, between estimated and actual BW. This was supported by Bland–Altman plots. For Hadlock 1 and 2, sensitivity was 80% with a NPV of 91%.

Conclusion:

The widely used Hadlock (1) and (2) formulas provided the best estimated BW in infants with gastroschisis despite its inclusion of abdominal circumference. Furthermore, this formula performs well with diagnosis of IUGR.

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Acknowledgements

This study was presented in poster format on 5 February 2016 at the 36th Annual Meeting of the Society of Maternal Fetal Medicine, Atlanta, Georgia held on 1–7 February 2016.

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Authors and Affiliations

  1. Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of California, Irvine, Orange, CA, USA

    M N Zaki & M Porto

  2. Division of Neonatology, Department of Pediatrics, University of California, San Francisco, San Francisco, CA, USA

    L A Lusk & M Liebowitz

  3. Division of Maternal-Fetal Medicine, Department of Reproductive Medicine, University of California, San Diego, San Diego, CA, USA

    R T Overcash

  4. Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, MedStar Washington Hospital Center, Washington, DC, USA

    R T Overcash

  5. Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of California, Los Angeles, Los Angeles, CA, USA

    R Rao

  6. Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of California, Davis, Davis, CA, USA

    Y N Truong

  7. Kaiser Permanente San Leandro, San Leandro, CA, USA

    Y N Truong

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  1. M N Zaki
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for the University of California Fetal Consortium (UCfC)

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Correspondence to M N Zaki.

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Zaki, M., Lusk, L., Overcash, R. et al. Predicting birth weight in fetuses with gastroschisis. J Perinatol 38, 122–126 (2018). https://doi.org/10.1038/jp.2017.171

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