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Volume 30 Issue 6, June 2023

Cover Credit: Transgene expression along retinal ganglion cell axons. Recombinant adeno-associated viral vectors (AAVs) have the capacity for efficient gene transfer in the retina. The strength and cell-selectivity of transgene expression are influenced by promoters. The cover article of this Gene Therapy issue investigated the impact of five short promoters on AAV2-mediated transgene expression in mice and ex vivo human retinal ganglion cells. The accompanying image illustrates a horizontal brain section of a mouse that received intravitreal injection of AAV2-SYN-eGFP. Notably, transgene expression is observed in the axons of retinal ganglion cells along the visual pathway.

Volume 30 Issue 6

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