Abstract
Objective:
To determine whether exercise augments the improvements in fractional synthetic rate (FSR) of albumin observed with nutrition alone.
Design:
Randomized crossover study. Each patient randomly participated in two protein metabolism kinetic studies using primed-constant infusion of (13C) leucine 2 h before, during and 2 h after hemodialysis. Plasma enrichments of (13C) leucine and (13C) ketoisocaproate were examined to determine the FSR of albumin.
Setting:
General Clinical Research Center at Vanderbilt University Medical Center.
Subjects:
Five chronic hemodialysis (CHD) patients.
Interventions:
Intra-dialytic parenteral nutrition (IDPN) with or without exercise.
Results:
Exercise performance during hemodialysis significantly improves the FSR of albumin beyond what is observed with IDPN alone (26.2±3.1% per day versus 17.7±1.9% per day, P<0.05).
Conclusion:
Exercise improves albumin fractional synthetic rate beyond what is observed with IDPN alone in the acute setting in CHD patients.
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Acknowledgements
The present work is partly supported by the National Institutes of Health Grants R01-DK45604, K24-DK62849 and DK-20593 from the National Institute of Diabetes, Digestive and Kidney Diseases, M01 RR-00095 from the National Center for Research Resources and Satellite Health Norman Coplon Extramural Grant Program. The excellent technical assistance of D Levenhagen, S Vaughan, J Harvell, M Zheng, P Egbert, F Moustofi and the nursing staff on the GCRC is appreciated. LB Pupim is an employee of Amgen Inc since August of 2005.
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Pupim, L., Flakoll, P. & Ikizler, T. Exercise improves albumin fractional synthetic rate in chronic hemodialysis patients. Eur J Clin Nutr 61, 686–689 (2007). https://doi.org/10.1038/sj.ejcn.1602578
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DOI: https://doi.org/10.1038/sj.ejcn.1602578
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