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Solving the pain puzzle

David Adam pieces together the recent gains in our understanding of pain.

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References

  1. Caterina, M.J. et al. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389, 816 - 824 1997.

    Article  ADS  CAS  Google Scholar 

  2. Caterina, M.J. et al. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 288, 306 - 313 2000.

    Article  ADS  CAS  Google Scholar 

  3. Davis, J.B. et al. Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia. Nature 405, 183 - 187 2000.

    Article  ADS  CAS  Google Scholar 

  4. Cockayne, D.A. et al. Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice. Nature 407, 1011 - 1015 2000.

    Article  ADS  CAS  Google Scholar 

  5. Souslova, V. et al. Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors. Nature 407, 1015 - 1017 2000.

    Article  ADS  CAS  Google Scholar 

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Adam, D. Solving the pain puzzle. Nature (2000). https://doi.org/10.1038/news001026-11

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  • DOI: https://doi.org/10.1038/news001026-11

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