Although some genetic mutations have clear effects, others have been considered neutral and inconsequential. Such cryptic mutations can nonetheless facilitate adaptation to new environments. See Letter p.92
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References
Hayden, E. J., Ferrada, E. & Wagner, A. Nature 474, 92–95 (2011).
Elena, S. F. & Lenski, R. E. Nature Rev. Genet. 4, 457–469 (2003).
Blount, Z. D., Borland, C. Z. & Lenski, R. E. Proc. Natl Acad. Sci. USA 105, 7899–7906 (2008).
Woods, R. J. et al. Science 331, 1433–1436 (2011).
Wagner, A. Robustness and Evolvability in Living Systems (Princeton Univ. Press, 2005).
Hermisson, J. & Wagner, G. P. Genetics 168, 2271–2284 (2004).
Draghi, J. A., Parsons, T. L., Wagner, G. P. & Plotkin, J. B. Nature 463, 353–355 (2010).
Masel, J. & Trotter, M. V. Trends Genet. 26, 406–414 (2010).
Schlichting, C. D. Ann. NY Acad. Sci. 1133, 187–203 (2008).
Jarosz, D. F. & Lindquist, S. Science 330, 1820–1824 (2010).
Provine, W. B. Sewall Wright and Evolutionary Biology (Chicago Univ. Press, 1986).
Bloom, J. D., Labthavikul, S. T., Otey, C. R. & Arnold, F. H. Proc. Natl Acad. Sci. USA 103, 5869–5874 (2006).
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Draghi, J., Plotkin, J. Hidden diversity sparks adaptation. Nature 474, 45–46 (2011). https://doi.org/10.1038/474045a
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DOI: https://doi.org/10.1038/474045a