Volume 31 Issue 6, June 2021

When synthetic biology meets RNAi therapy. Programmable genetic circuits (multicolor circles) utilize the liver as tissue chassis and a biogenerator, which can continuously produce and assemble exosome-encapsulated siRNAs (orange balls with spikes) for targeted delivery to multiple organs. See page 631–648 by Zheng Fu et al. for details.

This cover is designed by Tianxiang Lan.

Research Highlight

3D genome encoded by LINE and SINE repeats

Zhengyu Liang
Xiang-Dong Fu
Research Highlight 23 Feb 2021
Advertisement
A spatial map out of place

Adrien Peyrache
Adrian J. Duszkiewicz
Research Highlight 24 Feb 2021
Panning for brain antigens in dural sinuses

Ania Bogoslowski
Paul Kubes
Research Highlight 06 May 2021
LETN and NPM1 tango in human nucleoli

Guang Xu
Man Wu
Ling-Ling Chen
Research Highlight 12 May 2021
To learn something new, do something new

Adam M. P. Miller
Paul W. Frankland
Research Highlight 28 Apr 2021

Top of page ⤴

Article

Homotypic clustering of L1 and B1/Alu repeats compartmentalizes the 3D genome

J. Yuyang Lu
Lei Chang
Xiaohua Shen

Collection:

Editor’s selections: top articles from the past 3 years
Article Open Access 29 Jan 2021
In vivo self-assembled small RNAs as a new generation of RNAi therapeutics

Zheng Fu
Xiang Zhang
Xi Chen

Collection:

Editor’s selections: top articles from the past 3 years
Article Open Access 29 Mar 2021
A novel somatosensory spatial navigation system outside the hippocampal formation

Xiaoyang Long
Sheng-Jia Zhang
Article Open Access 18 Jan 2021
Mutual dependency between lncRNA LETN and protein NPM1 in controlling the nucleolar structure and functions sustaining cell proliferation

Xianteng Wang
Xiaolin Hu
Xuerui Yang
Article Open Access 11 Jan 2021
Sequential fate-switches in stem-like cells drive the tumorigenic trajectory from human neural stem cells to malignant glioma

Xiaofei Wang
Ran Zhou
Yuan Wang
Article Open Access 04 Jan 2021
BacFlash signals acid-resistance gene expression in bacteria

Di Wu
Wenfeng Qi
Xianhua Wang
Article 06 Nov 2020

Top of page ⤴

Letter to the Editor

Structural basis of human α7 nicotinic acetylcholine receptor activation

Yue Zhao
Sanling Liu
Changlin Tian
Letter to the Editor Open Access 06 May 2021
Structural basis for the different states of the spike protein of SARS-CoV-2 in complex with ACE2

Renhong Yan
Yuanyuan Zhang
Qiang Zhou
Letter Open Access 18 Mar 2021
The basis of a more contagious 501Y.V1 variant of SARS-CoV-2

Haolin Liu
Qianqian Zhang
Gongyi Zhang
Letter to the Editor 23 Apr 2021

Top of page ⤴

Volume 31 Issue 6, June 2021

Research Highlight

3D genome encoded by LINE and SINE repeats

A spatial map out of place

Panning for brain antigens in dural sinuses

LETN and NPM1 tango in human nucleoli

To learn something new, do something new

Article

Homotypic clustering of L1 and B1/Alu repeats compartmentalizes the 3D genome

In vivo self-assembled small RNAs as a new generation of RNAi therapeutics

A novel somatosensory spatial navigation system outside the hippocampal formation

Mutual dependency between lncRNA LETN and protein NPM1 in controlling the nucleolar structure and functions sustaining cell proliferation

Sequential fate-switches in stem-like cells drive the tumorigenic trajectory from human neural stem cells to malignant glioma

BacFlash signals acid-resistance gene expression in bacteria

Letter to the Editor

Structural basis of human α7 nicotinic acetylcholine receptor activation

Structural basis for the different states of the spike protein of SARS-CoV-2 in complex with ACE2

The basis of a more contagious 501Y.V1 variant of SARS-CoV-2

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