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The cover depicts a newly built elevated highway (replicating DNA) that is damaged (mismatch). A worker (MutS-MutL complex) identifies the damage and communicates with the repair department (Exo1) to fix the problem. The columns (buildings) represent chromatin remodeling and DNA metabolic proteins. Designed by Yipin Wu.See page 542-553 by Janice Ortega et al. for details.