Volume 28 Issue 11, November 2018

N6-methyladenosine (m6A) mRNA modification enhances learning efficacy, and overdosed training can compensate for the effect of m6A insufficiency. Cover image shows two tortoises with different levels of m6A modifications (shown as the numbers of hexagons on their shells) are competing in a race, which is an analogy to learning process. The tortoise with more m6A races more easily with less steps. However, if the one with less m6A pays more effort, the initial disadvantage can be overcome, and the two tortoises can finish the match at the same time. See page 1050-1061 by Zeyu Zhang et al. for details.