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The cover image illustrates that swordsmen (ROS-inducing drugs) are struggling against monsters (melanoma cells). However, when they are armed with iron robot (combined treatment of ROS-inducing drugs with iron), they easily destroy many monsters using a flame-thrower (ROS). Cover artwork is contributed by Xian-shuo Liu and Hui-ran Liu.See page 1171-1185 by Bo Zhou et al. for details.