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Cells and organisms adapt to mitochondrial dysfunction by activating the mitochondrial unfolded protein response (UPRmt), which is regulated by mitochondrial-to-nuclear communication; and UPRmt activation can also be transmitted between different cell types suggesting a role in tissue coordination. Shao and colleagues now identify a neuronal circuit and a secreted neuropeptide required for cell non-autonomous UPRmt regulation.
A recent paper published in Nature reports that the immunosuppressive activity of tumor-associated macrophages is regulated via PI3Kγ signaling. Small-molecule inhibitors targeting PI3Kγ stimulate T cell activity against tumor alone and add additional effects for clinically proven PD1 immunotherapy.
Recent evidence indicates that codon optimality is a broad determinant of mRNA stability. A study by Radhakrishnan et al. in Cell raises the possibility that the conserved DEAD-box protein Dhh1 underlies the phenomenon.
A near-atomic resolution structure of a mammalian voltage-gated calcium channel (Cav) has been determined. This first fully-assembled Cav structure illuminates mechanisms of Cav properties and functions and ushers in a new era in Cav research and beyond.
