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Zahedivash et al. undertake a single center retrospective analysis of patients less than 18 years of age with history of an arrhythmia to determine whether a wearable device can capture arrhythmias. Arrhythmias are identified in 28% of patients, mainly the difficult to identify supraventricular tachycardias.

Brück observes a decrease in the gender gap in the authorship of leading medical journals between 2010 and 2019, with some country-specific variation. This study provides a model approach for tracking gender representation in academic research.

Brück examines geographical representation in the authorship of leading medical journal publications between 2010 and 2019. While still dominated by authors from English-speaking countries, there is increased representation of authors from other countries over this period.

Alkobtawi, Ngô et al. conduct transcriptome and phenotype analyses of umbilical cord blood cells from pregnant women upon SARS-CoV-2 infection. In the absence of vertical SARS-CoV-2 transmission, erythroid cell signatures along with hypoxia pathway activation are observed in symptomatic infected mothers compared with control cases.

Stähli, Becchetti, Korta Martiartu et al. present a first-in-human evaluation of computed ultrasound tomography in echo mode to quantify the speed of sound in the liver. Estimated values show an excellent discriminative ability in distinguishing normal versus steatotic livers, with potential value in the non-invasive diagnosis of liver steatosis.

Jarvi and Balu-Iyer evaluate an immunogenicity screening toolbox in which in vitro assays capture the migratory potential of dendritic cells. Expression of the chemokine receptor CXCR4 on dendritic cells and their migration toward chemokines CCL21 and CXCL12 in the presence of therapeutic protein correlates with their clinical immunogenicity.

Seirin-Lee et al. develop a mathematical model to analyze the shapes of skin eruptions and link these morphological features to in vivo pathological dynamics of chronic urticaria. The proposed multidisciplinary method combining mathematical modelling, in vitro experiments, and clinical data, could constitute an innovative approach to the clinical treatment of an intractable disease.

Wang et al. use Mendelian randomization to study the causal interaction between physical activity, education, and BMI, finding that more physical activity leads to a lower BMI, while sedentary behavior is a consequence of higher BMI. More years of schooling encourages higher physical activity and lower BMI, emphasizing its positive impact on health.

Yoshioka, Taniguchi, Homma et al. study the effect of AAV-delivered Cas9 and specific guide RNAs to correct the PMP22 gene duplication that causes Charcot-Marie-Tooth disease type 1A. They measured the effect of Cas9 editing in iPSC cells on PMP22 expression and demonstrated how editing reduces cell death and myelination defects in edited iPSC-derived Schwann cells.

Avery et al. utilize data from the UK Biobank in a multivariable Mendelian randomization study to evaluate the effects of branched chain amino acids (BCAAs) on human disease. Their findings suggest observational studies of BCAA phenotypic effects are prone to substantial error, potentially misleading efforts to develop novel therapeutics.

Park et al. assess the therapeutic efficacy of mitochondrial transplantation with or without O-GlcNAc modification of isolated mitochondria. O-GlcNAcylation can prevent glycation while improving both the functional properties of mitochondria and the neuroprotective efficacy of transplantation in a mouse model of focal cerebral ischemia.

Cai et al. develop and evaluate mpox A29 surface envelop protein-based enzyme immunoassay to analyze seroprevalence and B cell responses after natural mpox viral infection or vaccination. The assay can readily detect mpox A29-specific B cells and antibody in the serum of mpox patients and MVA-BN vaccine recipients.

Caroppo, Calabrese et al. monitor the mental health of 100 asylum-seekers during a 14-day COVID19 related quarantine in reception facilities in Rome, Italy. Asylum-seekers are more likely to experience post-traumatic stress disorder than the general population, but a supportive environment during quarantine enhances their psychological well-being.

Rao and Rolston discuss recent challenges to foundational assumptions underlying responsive neurostimulation therapy for drug-resistant epilepsy. An emerging mechanistic model helps explain variability in clinical outcomes and suggests this therapy may have untapped potential for reducing seizures.

Ivancovsky-Wajcman et al. outline the need for a holistic preventive hepatology approach, involving social nutrition and social prescribing, to address the public health threat of metabolic dysfunction-associated steatotic liver disease (MASLD). They argue that this will facilitate individuals’ engagement in behavioural modifications to treat MASLD.

Bruneau et al. simulate high-fidelity fluid-structure interactions to model intracranial sounds. Spectrograms of the simulated vibrations are consistent with previously-reported microphone and Doppler ultrasound recordings.

Nilsson et al. distinguish between lower- and higher-grade prostate cancers using imaging and whole-slide histopathology in a co-registered dataset. They find that clinically significant distinctions of prostate cancer grades are reflected in partially discriminative cut-off values derived from multiparametric MRI and positron emission tomography.

Klenk, Erber et al. quantitatively detect blood cell aggregates in COVID-19 patients using label-free digital holographic microscopy. They find that COVID-19 severity associates with the amount of platelet and platelet leukocyte aggregates in the peripheral blood.

Langezaal, van den Broek, et al. develop a decision support system for epidemiological job coding. This system is used for occupational classification and exposure assessment of job descriptions and performs better than both expert coders and alternative currently available tools.