Diversity-oriented synthesis of glycomimetics

  • Michael Meanwell
  • Gaelen Fehr
  • Robert Britton
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    This month we thank Dr. Marco Chino from the University of Naples "Federico II", Italy. He designs peptides and proteins from scratch by means of computational tools and solid-phase synthesis.

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    This collection aims to uncover open questions across the breadth of the chemical sciences. Each Comment provides an overview of a focused field of research, identifies key open questions, and gives expert opinion on how challenges in answering these questions might be overcome.

  • Satoshi Honda

    In this interview in Nature Asia, Prof. Satoshi Honda from the University of Tokyo shares his view about the journal and the future of polymer chemistry.

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  • DNA-templated synthesis of chiral inorganic assemblies often requires chemical modification of the template. Now, a route exploiting the native chemistry of unmodified DNA origami templates provides access to 3D chiral assemblies.

    • Andrew J. Bissette
    Research Highlight Open Access
  • Water adsorption in soft nanoporous materials can trigger large-scale structural transitions and introduce new properties in the confined water phase. Here, we look at some of the outstanding questions in this lively field of research.

    • François-Xavier Coudert
    • Anne Boutin
    • Alain H. Fuchs
    Comment Open Access
  • The Hückel rule defines that monocyclic and planar conjugated systems containing [4n + 2] π electrons are aromatic. Here, the authors highlight boron species that feature a globally 4n π system, defying the Hückel rule, but nonetheless exhibit aromaticity.

    • Kei Ota
    • Rei Kinjo
    Comment Open Access
  • The commercial use of natural methane hydrate is hampered by several open questions that remain regarding hydrate formation. Here the authors comment on past interpretations and aim to provide a roadmap for developing a predictive theory of methane hydrate nucleation.

    • Guang-Jun Guo
    • Zhengcai Zhang
    Comment Open Access
  • The process of thermally activated delayed fluorescence (TADF) converts non-radiative triplet states into emissive singlet states. Herein we outline the fundamentals of TADF, some of the recent progress in understanding the key material properties responsible for promoting TADF and finally discuss some remaining challenges for the  potential applications of this phenomenon.

    • Julien Eng
    • Thomas J. Penfold
    Comment Open Access
Open Questions in Chemistry

Open Questions in Chemistry

In spite of decades of research and the enormous progress made, chemists continue to grapple with poorly understood aspects of the world around us. This collection aims to uncover open questions across the breadth of the chemical sciences. Each Comment provides an overview of a focused field of research, identifies key open questions, and gives expert opinion on how challenges in answering these questions might be overcome.
Collection

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