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A structural and functional characterization of salivary acid phosphatase-like proteins derived from the flea Xenopsylla cheopis demonstrating their ability to bind host biogenic amines and leukotrienes, potentially favouring blood acquisition.
A pan-cancer study indicates two mesenchymal-like tumor subtypes with distinct intrinsic or extrinsic driving mechanisms and could be used to guide chemotherapy and immune therapy.
Arsenic and ultraviolet radiation (UVR) are potent carcinogens. This study shows that a co-exposure to both arsenic and UVR leads to an accelerated mouse skin carcinogenesis due to an enhanced accumulation of UVR-associated somatic mutations.
Structural and biophysical characterization of a small molecule binding to Cbl-b E3 ligase reveals an intramolecular glue mechanism locking the protein in an inactive state.
A combination of quantitative proteomics and functional analyses in a T-cell line unveils a role for the centriolar satellite component CEP131 in the maintenance of proteostasis and the fine-tuning of mitochondrial apoptosis.
In Drosophila melanogaster, the red-shifted bioluminescence system Akaluc/AkaLumine is useful for studying gene expression, cell numbers, and innate immunity levels in deep tissues without harming the individual.
A study of the evolution of the RCOR-LSD1 epigenetic complex sheds light on its evolutionary origin, the role of whole genome duplications in its evolution, and the conservation of the structure of the protein complex in the gnathostome ancestor.
A neurobiological study reveals Gtf2i’s pivotal roles in brain development and mediating neuronal mitochondrial function, validated by human brain samples derived from individuals with Williams syndrome.
A nutritive hydrogel enhances the survival of human mesenchymal stromal cells by providing physiological glucose levels in a controlled manner, eliciting new blood vessel formation in vivo.
scPML is a pathway-based multi-view learning model that outperforms alternative approaches in cell type annotation and detecting unknown cell types across diverse species, platforms, and tissues.
An updated, chromosome-scale genome assembly of quinoa enables the characterization of subgenome dynamics, including the identification of large structural rearrangements. The B subgenome is also more dynamic and has expanded more than the A subgenome.
The study shows, by comparing CoV2 vs flu infection, that CoV2 infection fails to induce of Krt5+ “pod” formation and cell proliferation and mediates more profound chronic effects on the lungs including fibrotic abnormalities than flu infection.
In vivo recordings show that a subset of supramammillary neurons that project to the medial septum are wake-active, and projection-specific manipulations reveal that this hypothalamic-septal projection contributes to wakefulness modulation.
Joint connectomic and transcriptomic analyses of longitudinal dMRI data reveal the multiscale developmental pattern of the human white matter connectome from childhood to adolescence.
Short-term tracking of treefrogs in southern Brazil, alongside microbiome and stress hormone profiling, suggests that forest fragmentation impacts microbiome diversity and composition, and that these changes might be mediated by the host stress response.
A super-resolution light-field imaging method enables video-rate 3D imaging of intracellular dynamics beyond diffraction limit and with strong noise-resistant capability.
New palaeodictyopteran larvae show similar form and surface microstructures on lateral abdominal outgrowths and thoracic wing pads, suggesting that paired serial outgrowths on segments of both tagmata functioned as ancestral type of gills, resembling a protopterygote model.
Network-based restoration strategies that prioritize the reintroduction of highly connected species maximize the recovery of biodiversity following ecosystem collapse.
An NMR study on K113-ubiquitinated BAK complex reveals that the conjugated ubiquitin subunit binds to the canonical hydrophobic groove of BAK, which prevents the binding of prodeath BH3 activators and impairs BH3-induced BAK apoptotic activity.
Super-resolution imaging and RNA clock analyses show that exposure of mouse oocytes to ionizing radiation compromises chromatin organization and dramatically accelerates biological aging.