Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain
the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in
Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles
and JavaScript.
Striatal projection neurons expressing the D1 or D2 dopamine receptors are probed for translating mRNAs and DNA modifications, identifying differential methylation signatures between the cell types and genome-wide hydroxymethylation asymmetry between the two DNA strands.
A meta-analysis of pre-pregnancy maternal body mass index (ppBMI) and placental DNA methylation from 2631 mother-child pairs identifies 27 CpG sites associated with ppBMI, providing insight into how maternal obesity could be associated with metabolic health outcomes in offspring.
An extensive protein-interaction network of cell-wall biosynthesis assemblies in P. aeruginosa is elucidated using a pulldown strategy with mass-spectrometry-based proteomics and binding assays.
The oncogenic ability of mutant CARD11 (E626K), one of most frequently mutated genes in adult T-cell leukemia and its cooperative effect with HBZ expression, using the CD4 promoter-driven HBZ transgenic mouse model, is investigated.
Phylogenetic analyses and physiological experiments indicate that the regulatory domain of plant proton pumps could have been key in the plant transition to land from water.
Analysis of sleep states in the rough-tail rock agama lizard suggests neurophysiological similarity between reptilian and mammalian two-state sleep features. In contrast to mammals, these features remain robust to the large temperature fluctuations experienced by reptiles.
Asia is shown to be behind in meeting the Aichi Target 11 under the Convention on Biological Diversity and current trends indicate that 2030 targets are unlikely to be achieved with severe impact on biodiversity.
Osteohistology from a growth series of Whatcheeria, an Early Carboniferous stem tetrapod, indicates rapid juvenile growth dating back to tetrapod origins.
Using whole genome sequencing and broad sampling across the nation, the genetic diversity of the malaria mosquito An. minimus across Cambodia is described.
Combination of proximity biotinylation and protein cross-linking allows proximity phosphoproteomics of the kinetochore in Leishmania parasites during the cell cycle and captures perturbations at the kinetochore after treatment with a protein kinase inhibitor.
Functional ultrasound imaging of rats reveals that the amygdala was disconnected from global activation of the rest of the brain during REM sleep, suggesting that the amygdala may undergo more specific processing during REM sleep.
The combination of laboratory and semifield experiments, paired with surveillance data, demonstrate the natural timeline for mosquito diapause, highlighting the importance of latitude and population genetics.
The interplay of mesenchymal and endothelial cells with breast cancer (BC) cells are investigated in a synthetic tumor microenvironment mimics (STEM) and CAM model to assess migration and metastasis.
A pseudotime analysis of the host cell response to SARS-CoV-2 infection using publicly available scRNA-seq data derived from in vitro studies reveals a non-lineal, triphasic transcriptional response and suggests a global regulatory mechanism.
The genetic alterations, protein expressions, and clinical characteristics of growth hormone-producing pituitary adenomas/somatotroph pituitary neuroendocrine tumors are integrated to detect molecules associated with acromegaly characteristics.
Multimodal single-cell analysis on iPSC-derived kidney organoids shows that inhibiting EZH2 attenuates TGFβ1-induced fibrotic gene expression and changes in chromatin accessibility, highlighting a potential therapeutic strategy for renal fibrosis.
Members of the conserved TOG/XMAP215 family possess microtubule polymerase activities; however, Dis1 in fission yeast is shown to promote microtubule catastrophe.
Selective DREADD-mediated activation of the lateral septum reveals its importance in enabling male prairie voles to adjust selective and nonselective social behavior to account for important life-history shifts linked with reproductive success.
A Neisseria cinerea Cas9 variant is characterised in PAM preference, editing efficiency (for both nuclease and base editing) and anti-CRISPR protein blocking, with a PAM of (N)4GYAT reported alongside a mouse zygote assay.
Multivariate brain-behaviour associations are studied with regularized canonical correlation analysis and a machine learning framework, showing that behavioural inter-individual variability is linked to inter-individual variability in brain structure.