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Interneuron-specific lines reveal that somatostatin interneurons are hyperactive whereas pyramidal neurons and PV interneurons are ‘hypoactive’ in the APP/PS1 mouse model of Alzheimer’s Disease.
An improved method for in-cell NMR is developed using a reporter to evaluate protein delivery and delivery parameters to different cell lines and applied to IDPs and folded proteins including structure determination of GB1 at 1.1 Å resolution.
Characterisation of macrophages from human carotid artery plaques and in vitro assays reveal that macrophages regulate vascular smooth muscle cell function during atherosclerosis progression through the IL-1β/STAT3 axis.
Mycobacterium tuberculosis senses IFN-γ via the membrane protein MmpL10, which results in stimulation of bacterial respiration and virulence gene expression, worsens infection and paradoxically prevents the formation of isoniazid tolerant persisters.
Striatal projection neurons expressing the D1 or D2 dopamine receptors are probed for translating mRNAs and DNA modifications, identifying differential methylation signatures between the cell types and genome-wide hydroxymethylation asymmetry between the two DNA strands.
A meta-analysis of pre-pregnancy maternal body mass index (ppBMI) and placental DNA methylation from 2631 mother-child pairs identifies 27 CpG sites associated with ppBMI, providing insight into how maternal obesity could be associated with metabolic health outcomes in offspring.
An extensive protein-interaction network of cell-wall biosynthesis assemblies in P. aeruginosa is elucidated using a pulldown strategy with mass-spectrometry-based proteomics and binding assays.
The oncogenic ability of mutant CARD11 (E626K), one of most frequently mutated genes in adult T-cell leukemia and its cooperative effect with HBZ expression, using the CD4 promoter-driven HBZ transgenic mouse model, is investigated.
Phylogenetic analyses and physiological experiments indicate that the regulatory domain of plant proton pumps could have been key in the plant transition to land from water.
Analysis of sleep states in the rough-tail rock agama lizard suggests neurophysiological similarity between reptilian and mammalian two-state sleep features. In contrast to mammals, these features remain robust to the large temperature fluctuations experienced by reptiles.
Asia is shown to be behind in meeting the Aichi Target 11 under the Convention on Biological Diversity and current trends indicate that 2030 targets are unlikely to be achieved with severe impact on biodiversity.
Osteohistology from a growth series of Whatcheeria, an Early Carboniferous stem tetrapod, indicates rapid juvenile growth dating back to tetrapod origins.
Using whole genome sequencing and broad sampling across the nation, the genetic diversity of the malaria mosquito An. minimus across Cambodia is described.
Combination of proximity biotinylation and protein cross-linking allows proximity phosphoproteomics of the kinetochore in Leishmania parasites during the cell cycle and captures perturbations at the kinetochore after treatment with a protein kinase inhibitor.
Functional ultrasound imaging of rats reveals that the amygdala was disconnected from global activation of the rest of the brain during REM sleep, suggesting that the amygdala may undergo more specific processing during REM sleep.
The combination of laboratory and semifield experiments, paired with surveillance data, demonstrate the natural timeline for mosquito diapause, highlighting the importance of latitude and population genetics.
The interplay of mesenchymal and endothelial cells with breast cancer (BC) cells are investigated in a synthetic tumor microenvironment mimics (STEM) and CAM model to assess migration and metastasis.