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Microfluidic model of human gingival tissue with complex oral tissue architecture allows monthlong phenotypic expression, response and recovery to multiple inflammatory triggers and the potential for identification of new therapeutic targets for gum disease.
Electron microscopic visualization and movement analysis of the gliding machinery in Bacteroidetes provide insights into the mechanism of gliding motility, or the ability of these microbes to move on solid surfaces.
The chloride channel anoctamin1, upon activation by calcium influx through transient receptor potential vanilloid 3, mediates chloride influx and enhances wound healing in keratinocytes.
The analysis of viral RNA shedding and emission dynamics for 14 diverse influenza viruses in ferrets reveals that efficient ferret-to-ferret transmission via air is directly associated with robust emission of virus-laden particles at early times.
The analysis of mitochondrial DNA from over 8000 metazoans shows gene content conservation, association between preference for mtDNA-encoded tRNAs and codon usage, selective constraint for mtDNA rearrangements and their impact on mtDNA transcription.
Multi-omic and evolutionary analyses of the ultrasmall green algae, Medakomo hakoo, suggest that it might belong to a new genus within the class Trebouxiophyceae and provide further insight into the essential genes for microalgae.
A new clearing and imaging technique termed iCBiofilm is developed for imaging whole bacterial and fungal biofilms using confocal laser scanning microscopy, which enables examining the dynamics and functions of biofilms.
A scRNA-seq analysis of human mucinous adenocarcinoma vs. classical adenocarcinoma provides insight into the molecular differences between these two subtypes of colorectal cancer.
Larval zebrafish are subjected to ototoxic compounds to evaluate their impact on rheotaxis, and compound-specific behaviour profiles reveal unique effects on zebrafish rheotaxis behavior.
An NMR-centered approach demonstrates that the liquid-liquid phase separation behavior of the SARS-CoV-2 nucleocapsid (N) protein is modulated by competitive interactions with ATP and nucleic acids.
The vibroacoustic and chemical alarm communication in the wood roach Cryptocercus and in 20 termite species are studied to reveal that the Neoisoptera species have developed the most sophisticated communication system, which could contribute towards their ecological success.
A computational pipeline and webserver identify regulators of RNA-binding proteins (RBPs) at single-cell resolution and are applied to determine the role of RBP HNRNPK in cancer.
In a cardiomyocyte hypertrophy model with aberrant Wnt activation, proteomic analysis of extracellular vesicles and transcriptomic profiling reveal a proteostasis signature for early patho-physiological states of cardiomyocytes.
In peripheral blood mononuclear cells from healthy human donors, the superantigens SpeC and TSST-1 are shown to specifically activate TRBV12-3/12-4+ memory T cells.
Signatures associated with COVID-19 disease severity are studied, primarily using machine learning models for classification on the basis of TCR repertoire analysis and combining such data/analysis with single cell transcriptomic data.
Optogenetic or pharmacological modulation of hypocretin neurons impacts mouse impulsivity in a Go/No-Go task, suggesting that these neurons play a key role in integrating salient stimuli and guiding responses to various environmental cues.
An ensemble deep learning model (EDLM)-based protein-protein interaction (PPI) site identification method (EDLMPPI) accurately predicts PPIs through protein language models and outperforms state-of-the-art methods on multiple benchmark sets.