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The X-ray crystal structure of a SUN1-KASH6 complex reveals an asymmetric trimer-of-trimers LINC complex architecture that fulfils the steric requirements for its biological role in transmitting cytoskeletal forces across the nuclear envelope.
Proteomics of waste intermediates from industrial plasma fractionation samples revealed new candidate therapeutic proteins such as ceruloplasmin, which reverted central nervous system and peripheral deficits in ceruloplasmin-deficient mice.
A study on human and mice using 16SrRNA gene sequencing and targeted metabolomic analysis suggests that iodine intake alters intestinal microbiota composition and metabolic changes influencing the microbiota-gut-thyroid axis.
Specially folded G-quadruplex of short RNAs have the capacity to form solid-like aggregates. The aggregation of these short RNAs is clearly observable both in cells and in vivo, resulting in the suppression of cell clonogenicity and eventual cell death.
Bacteriophages displaying amyloidogenic peptides are able to identify amyloid-beta oligomers in post-mortem brain tissue of APP/PS1-transgenic mice and of Alzheimer patients.
An 18-member and a 4-member community consisting of commensal bacterial strains protected mice against C. difficile infection. The benefit of the 4-member community is mediated by secreted product(s) and not only by the bacteria, by proteolyzing clostridial toxins.
A single-cell interaction study on ovarian cancer reveals heterogeneous epithelial-immune-stromal cellular compartments and their interactions in shaping the tumor microenvironment, especially through the NECTIN2-TIGIT interaction.
Fusarium venenatum is a potential protein source in Caenorhabditis elegans and mice that exhibits anti-obesity properties by improving lipid profiles and reducing fat accumulation.
Cortistatin (CST) may have the capability to prevent GC-induced apoptosis and metabolic disorder of osteoblasts in the pathogenesis of ONFH via the GHSR1a/AKT signaling pathway.
KLF15 transcriptionally activates LINC00689, leading to the stabilization of LATS2 mRNA by recruiting PTBP1, which in turn suppresses colorectal tumorigenesis by inhibiting oncogenes like YAP1 and β-catenin.
An EEG study involving autistic adults indicates that the neurophysiological profile of autistic females during automatic face processing lies intermediate between that of autistic males and non-autistic individuals.
Neudesin is identified as an inhibitor of erythrophagocytosis by red pulp macrophages in the spleen. Its deficiency shortened RBC lifespan, and impaired recovery from induced acute anemia in young mice, and led to severe anemia in older mice.
Low concentrations of the anthelmintic parbendazole (PBZ) induces monocytic differentiation in AML cells and PBZ could be a candidate for drug repositioning.
The phosphorylated pathway of serine biosynthesis plays a critical role in growth and development, and affects the tricarboxylic acid cycle, the amino acid and nucleotide metabolism and lipid metabolism in Marchantia polymorpha.
An integrated epidemiological, immunological, and structural study suggests that the broadly neutralizing antibodies against Zika virus could be induced from dengue-infected individuals initially primed with Japanese encephalitis virus.
Study of 459,119 UK Biobank participants reveals that type 2 diabetes (T2D) and a high genetic susceptibility to T2D significantly increase the severity and mortality rate in COVID-19 cases.
Long-term monitoring revealed that a prolonged marine heatwave drove a profound transition in pelagic microbial assemblages, altering seasonal patterns of diversity and shifting niche conditions to those observed over 1000 km equatorward.
During the dauer state, when worms are quiescent and do not need to feed, their gut becomes a storage unit for cholesterol. This sterol is later needed to exit quiescence via a transcriptional change and activation of growth by mTOR.
Single-cell RNA sequencing identifies the composition of chondrosarcomas and reveals an association between endoplasmic reticulum stress and malignant transformation.