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Fusarium venenatum is a potential protein source in Caenorhabditis elegans and mice that exhibits anti-obesity properties by improving lipid profiles and reducing fat accumulation.
Cortistatin (CST) may have the capability to prevent GC-induced apoptosis and metabolic disorder of osteoblasts in the pathogenesis of ONFH via the GHSR1a/AKT signaling pathway.
KLF15 transcriptionally activates LINC00689, leading to the stabilization of LATS2 mRNA by recruiting PTBP1, which in turn suppresses colorectal tumorigenesis by inhibiting oncogenes like YAP1 and β-catenin.
An EEG study involving autistic adults indicates that the neurophysiological profile of autistic females during automatic face processing lies intermediate between that of autistic males and non-autistic individuals.
Neudesin is identified as an inhibitor of erythrophagocytosis by red pulp macrophages in the spleen. Its deficiency shortened RBC lifespan, and impaired recovery from induced acute anemia in young mice, and led to severe anemia in older mice.
Low concentrations of the anthelmintic parbendazole (PBZ) induces monocytic differentiation in AML cells and PBZ could be a candidate for drug repositioning.
The phosphorylated pathway of serine biosynthesis plays a critical role in growth and development, and affects the tricarboxylic acid cycle, the amino acid and nucleotide metabolism and lipid metabolism in Marchantia polymorpha.
An integrated epidemiological, immunological, and structural study suggests that the broadly neutralizing antibodies against Zika virus could be induced from dengue-infected individuals initially primed with Japanese encephalitis virus.
Study of 459,119 UK Biobank participants reveals that type 2 diabetes (T2D) and a high genetic susceptibility to T2D significantly increase the severity and mortality rate in COVID-19 cases.
Long-term monitoring revealed that a prolonged marine heatwave drove a profound transition in pelagic microbial assemblages, altering seasonal patterns of diversity and shifting niche conditions to those observed over 1000 km equatorward.
During the dauer state, when worms are quiescent and do not need to feed, their gut becomes a storage unit for cholesterol. This sterol is later needed to exit quiescence via a transcriptional change and activation of growth by mTOR.
Single-cell RNA sequencing identifies the composition of chondrosarcomas and reveals an association between endoplasmic reticulum stress and malignant transformation.
Cannabinol (CBN) is a promising compound that is suggested as an analgesic. Using electrophysiological techniques, this study determined that CBN inhibits the sodium currents associated with pain signaling, with potential application for neuropathic pain.
In situ super-resolution imaging of underwound DNA reveals that the nucleolar shell provides anchoring sites that constrain DNA axial rotation for RNA polymerase I-driven DNA underwinding.
A single-unit electrophysiology study with awake macaques suggests that a conflict is detected fast by frontal eye field neurons, while it is much slower resolved and in a complex manner, depending on the specific task rules and individual strategies.
A study on clinical tissue specimens and a porcine model reveals that S100A8/A9 mediates endometrial stromal cell fibrosis and IUA by activating the RAGE-JAK2-STAT3 pathway. These effects can be ameliorated through MenSCs transplantation.
An EEG study reports sound-induced suppression of the earliest visual cortical activity in a rare group of humans who were born pattern vision blind but regained sight, indicating persistent crossmodal visual cortical activation after sight recovery.
The study reveals the diversity, specificity and functionality of phyllosphere endophytes in alfalfa silage fermentation and finds a unique microbe resource in phyllosphere endophytes which tends to enrich genes related to carbohydrate utilization.