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TMEM16A acts in smooth muscle cells as a critical pacemaker channel that enables the internal anal sphincter to contract rhythmically and continuously, a critical phenomenon to allow for fecal continence.
Combined transcriptomics and proteomics of skin and lymphoid organs reveal the significance of SPINK5 in the regulation of protease activity and systemic inflammation, providing a conserved molecular framework for Netherton syndrome.
Single-molecule DNA manipulations experiments reveal that the TRF2 component of the telomeric-specific complex exhibits multiple DNA-binding modes on telomeric DNA that can switch between extended and compact conformations with no strong preference for DNA supercoiling chirality under tension.
The authors use phage display to develop dual-specific single-chain variable fragments against DNA and N-pyrrolated proteins, providing mechanistic insights into the multi-specificity of anti-DNA antibodies.
A stable isotope study elucidated a nutrient recycling pathway in which the coral holobiont incorporates nutrients from sponge-derived matter and interspecific differences in incorporation align with ecophysiological characteristics of the coral.
Small and large-scale movements are observed in the dark-adapted state of a photoactivated adenylate cyclase from the cyanobacterium Oscillatoria acuminata upon ATP binding using fluorescence and solution X-ray scattering methods.
An fMRI study suggests that epilepsy-related perturbations of spontaneous brain activity affect macroscale intrinsic dynamics and microcircuit organizations, and that they are highly spatially correlated.
An assay-based laboratory study that defines precompetency durations of 2 – 6 days and compares settlement preference amongst common inducers, for 25 Scleractinian Indo-Pacific coral species.
A new restoration approach reveals that planting ‘Reef Carpets’ instantly generates ecological habitats for coral-associated organisms and supports coral recruitment, providing an innovative tool to scaleup reef restoration and biodiversity benefits.
An interaction between hepatocyte nuclear factor 4A (HNF4A) and the MLL4 complex is important for histone modifications at cis regulatory regions to alter gene expression in vivo and in vitro.
When choosing equal breeding sites, gravid Aedes aegypti aggregate more often than expected. This aggregation depends on the number of females present and involves a density-regulated avoidance response that relies on Orco and the CO2 receptor, Gr3.
A large-scale genome-wide association study reveals that host genome strongly correlates with nasal microbiota diversity, taxa, and functions, suggesting a relationship between human genetic variation and the nasal microbiome.
The X-ray crystal structure of a SUN1-KASH6 complex reveals an asymmetric trimer-of-trimers LINC complex architecture that fulfils the steric requirements for its biological role in transmitting cytoskeletal forces across the nuclear envelope.
Proteomics of waste intermediates from industrial plasma fractionation samples revealed new candidate therapeutic proteins such as ceruloplasmin, which reverted central nervous system and peripheral deficits in ceruloplasmin-deficient mice.
A study on human and mice using 16SrRNA gene sequencing and targeted metabolomic analysis suggests that iodine intake alters intestinal microbiota composition and metabolic changes influencing the microbiota-gut-thyroid axis.
Specially folded G-quadruplex of short RNAs have the capacity to form solid-like aggregates. The aggregation of these short RNAs is clearly observable both in cells and in vivo, resulting in the suppression of cell clonogenicity and eventual cell death.
Bacteriophages displaying amyloidogenic peptides are able to identify amyloid-beta oligomers in post-mortem brain tissue of APP/PS1-transgenic mice and of Alzheimer patients.
An 18-member and a 4-member community consisting of commensal bacterial strains protected mice against C. difficile infection. The benefit of the 4-member community is mediated by secreted product(s) and not only by the bacteria, by proteolyzing clostridial toxins.
A single-cell interaction study on ovarian cancer reveals heterogeneous epithelial-immune-stromal cellular compartments and their interactions in shaping the tumor microenvironment, especially through the NECTIN2-TIGIT interaction.