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  • Article
    | Open Access

    Alqassim et al find that RNA editing, known to be induced by IFN-1 in macrophages by the enzyme APOBEC3A, is required for the transcriptional, pro-inflammatory and metabolic responses that drive M1 macrophage polarization. APOBEC3A-mediated editing is also induced by IFN-1 exposure in tumor-associated macrophages isolated from ovarian cancer-related ascites fluid, pointing to a wide role for APOBEC3A in macrophages.

    • Emad Y. Alqassim
    • , Shraddha Sharma
    • , A. N. M. Nazmul H. Khan
    • , Tiffany R. Emmons
    • , Eduardo Cortes Gomez
    • , Abdulrahman Alahmari
    • , Kelly L. Singel
    • , Jaron Mark
    • , Bruce A. Davidson
    • , A. J. Robert McGray
    • , Qian Liu
    • , Brian D. Lichty
    • , Kirsten B. Moysich
    • , Jianmin Wang
    • , Kunle Odunsi
    • , Brahm H. Segal
    •  & Bora E. Baysal
  • Article
    | Open Access

    He et al. assessed different parameters of tactile processing in children diagnosed with autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD). They found evidence for disorder-specific alterations of lower-level sensory processing, which can be related back to higher-level clinical symptoms.

    • Jason L. He
    • , Ericka Wodka
    • , Mark Tommerdahl
    • , Richard A. E. Edden
    • , Mark Mikkelsen
    • , Stewart H. Mostofsky
    •  & Nicolaas A. J. Puts
  • Article
    | Open Access

    Jeremy Gauthier et al. present the chromosome scale assembly of the genome of the parasitic wasp C. congregata and show that bracovirus genes have colonized all ten chromosomes. Comparison with genome scaffolds of another wasp reveals a striking stability of these regions over ~53 million years, suggesting strong evolutionary constraints.

    • Jérémy Gauthier
    • , Hélène Boulain
    • , Joke J. F. A. van Vugt
    • , Lyam Baudry
    • , Emma Persyn
    • , Jean-Marc Aury
    • , Benjamin Noel
    • , Anthony Bretaudeau
    • , Fabrice Legeai
    • , Sven Warris
    • , Mohamed A. Chebbi
    • , Géraldine Dubreuil
    • , Bernard Duvic
    • , Natacha Kremer
    • , Philippe Gayral
    • , Karine Musset
    • , Thibaut Josse
    • , Diane Bigot
    • , Christophe Bressac
    • , Sébastien Moreau
    • , Georges Periquet
    • , Myriam Harry
    • , Nicolas Montagné
    • , Isabelle Boulogne
    • , Mahnaz Sabeti-Azad
    • , Martine Maïbèche
    • , Thomas Chertemps
    • , Frédérique Hilliou
    • , David Siaussat
    • , Joëlle Amselem
    • , Isabelle Luyten
    • , Claire Capdevielle-Dulac
    • , Karine Labadie
    • , Bruna Laís Merlin
    • , Valérie Barbe
    • , Jetske G. de Boer
    • , Martial Marbouty
    • , Fernando Luis Cônsoli
    • , Stéphane Dupas
    • , Aurélie Hua-Van
    • , Gaelle Le Goff
    • , Annie Bézier
    • , Emmanuelle Jacquin-Joly
    • , James B. Whitfield
    • , Louise E. M. Vet
    • , Hans M. Smid
    • , Laure Kaiser
    • , Romain Koszul
    • , Elisabeth Huguet
    • , Elisabeth A. Herniou
    •  & Jean-Michel Drezen
  • Article
    | Open Access

    Rook et al. establish a viral gene transfer system to perform optogenetics in pigeons. They deliver ChR2 via AAV1 into the visual entopallium and show its behavioral relevance for contrast perception, verifying the applicability of optogenetics in an avian species.

    • Noemi Rook
    • , John Michael Tuff
    • , Sevim Isparta
    • , Olivia Andrea Masseck
    • , Stefan Herlitze
    • , Onur Güntürkün
    •  & Roland Pusch
  • Article
    | Open Access

    Anzai et al. propose a deep learning approach to estimate the 3D hemodynamics of complex aorta-coronary artery geometry in the context of coronary artery bypass surgery. Their method reduces the calculation time 600-fold, while allowing high resolution and similar accuracy as traditional computational fluid dynamics (CFD) method.

    • Gaoyang Li
    • , Haoran Wang
    • , Mingzi Zhang
    • , Simon Tupin
    • , Aike Qiao
    • , Youjun Liu
    • , Makoto Ohta
    •  & Hitomi Anzai
  • Article
    | Open Access

    Using integrative tissue-omics, Lage-Vickers, Bizzotto et al. classify prostate cancer patients into high YWHAZ and NDRG1 expression subgroups that correlate with a high and intermediate risk of disease progression. This study identifies molecular biomarkers associated with aggressive prostate cancer.

    • Sofia Lage-Vickers
    • , Juan Bizzotto
    • , Maria Pia Valacco
    • , Pablo Sanchis
    • , Sergio Nemirovsky
    • , Estefania Labanca
    • , Carlos Scorticati
    • , Osvaldo Mazza
    • , Antonina Mitrofanova
    • , Nora Navone
    • , Elba Vazquez
    • , Javier Cotignola
    •  & Geraldine Gueron
  • Article
    | Open Access

    Yaodong Yang et al. report a chromosome-scale genome assembly of the coconut and transcriptome analysis of coconut leaves. Their analysis reveals important steps along the evolutionary trajectory of palms and identifies genes that may play a key role in tolerance to salt stress.

    • Yaodong Yang
    • , Stéphanie Bocs
    • , Haikuo Fan
    • , Alix Armero
    • , Luc Baudouin
    • , Pengwei Xu
    • , Junyang Xu
    • , Dominique This
    • , Chantal Hamelin
    • , Amjad Iqbal
    • , Rashad Qadri
    • , Lixia Zhou
    • , Jing Li
    • , Yi Wu
    • , Zilong Ma
    • , Auguste Emmanuel Issali
    • , Ronan Rivallan
    • , Na Liu
    • , Wei Xia
    • , Ming Peng
    •  & Yong Xiao
  • Article
    | Open Access

    Matsuo, Isosaka, et al report that innate fear, but not learned fear, in mice results in systemic hypothermia/hypometabolism and suppressed aerobic metabolism, which enables survival in hypoxic environments. They demonstrate that this process is orchestrated via the brain stem Sp5/NST to midbrain PBN pathway. This study provides insight into the relationship between innate fear and its intrinsic life protective abilities

    • Tomohiko Matsuo
    • , Tomoko Isosaka
    • , Lijun Tang
    • , Tomoyoshi Soga
    • , Reiko Kobayakawa
    •  & Ko Kobayakawa
  • Article
    | Open Access

    Wu, Niu, Cui et al characterize G4 motifs across 37 species by bioinformatics, revealing that G4 complexity increases with evolution and as well as an antagonistic relationship between the potential G4s and DNA methylation sites.

    • Feng Wu
    • , Kangkang Niu
    • , Yong Cui
    • , Cencen Li
    • , Mo Lyu
    • , Yandong Ren
    • , Yanfei Chen
    • , Huimin Deng
    • , Lihua Huang
    • , Sichun Zheng
    • , Lin Liu
    • , Jian Wang
    • , Qisheng Song
    • , Hui Xiang
    •  & Qili Feng
  • Article
    | Open Access

    Nabil Benzina et al. use a reversal learning task to examine behavioral flexibility in human and mouse models of obsessive compulsive disorder (OCD). They report that only subsets of human patients or OCD-like mice show deficits in behavioral flexibility, highlighting the diverse presentation of cognitive deficits in compulsive disorders.

    • Nabil Benzina
    • , Karim N’Diaye
    • , Antoine Pelissolo
    • , Luc Mallet
    •  & Eric Burguière
  • Article
    | Open Access

    Dong Won Kim and colleagues investigate the mechanisms by which hypothalamic GABAergic neurons differentiate during development. They report that Lhx6 is crucial for the survival of hypothalamic neurons.

    • Dong Won Kim
    • , Kai Liu
    • , Zoe Qianyi Wang
    • , Yi Stephanie Zhang
    • , Abhijith Bathini
    • , Matthew P. Brown
    • , Sonia Hao Lin
    • , Parris Whitney Washington
    • , Changyu Sun
    • , Susan Lindtner
    • , Bora Lee
    • , Hong Wang
    • , Tomomi Shimogori
    • , John L. R. Rubenstein
    •  & Seth Blackshaw
  • Article
    | Open Access

    Snijders et al. present a field-based experimental study of the effects of group size and sex composition on social foraging in Trinidadian guppies. Their results indicate that sex differences in sociality do not necessarily imply an unequal ability to benefit from social presence.

    • Lysanne Snijders
    • , Stefan Krause
    • , Alan N. Tump
    • , Michael Breuker
    • , Chente Ortiz
    • , Sofia Rizzi
    • , Indar W. Ramnarine
    • , Jens Krause
    •  & Ralf H.J.M. Kurvers
  • Article
    | Open Access

    Here, the authors identify potential drugs that target 3-chymotrypsin like protease (3CLpro), which is a pivotal protease for the replication of SARS-CoV-2. They found that off-target inhibitors such as ivermectin and micafungin inhibit 3CLpro enzyme activity, suggesting that these molecules could constitute useful therapies to inhibit SARS-CoV-2 replication.

    • Vicky Mody
    • , Joanna Ho
    • , Savannah Wills
    • , Ahmed Mawri
    • , Latasha Lawson
    • , Maximilian C. C. J. C. Ebert
    • , Guillaume M. Fortin
    • , Srujana Rayalam
    •  & Shashidharamurthy Taval
  • Article
    | Open Access

    Nakabayashi et al find that the E3 ligase MIB2 ubiquitylates the apoptosis-inhibitor cFLIP and that deletion of MIB2 enhances both RIPK1 kinase-dependent and -independent apoptosis through an increase in RIPK1 kinase activity and impairment of ubiquitylation of cFLIPL, respectively.

    • Osamu Nakabayashi
    • , Hirotaka Takahashi
    • , Kenta Moriwaki
    • , Sachiko Komazawa-Sakon
    • , Fumiaki Ohtake
    • , Shin Murai
    • , Yuichi Tsuchiya
    • , Yuki Koyahara
    • , Yasushi Saeki
    • , Yukiko Yoshida
    • , Soh Yamazaki
    • , Fuminori Tokunaga
    • , Tatsuya Sawasaki
    •  & Hiroyasu Nakano
  • Article
    | Open Access

    Blaskovich et al. demonstrate the antimicrobial applications of cannabidiol and cannabidiol analogs against a range of pathogenic bacteria, including the capacity to kill MRSA and the Gram-negative bacteria Neisseria gonorrhoeae. This article highlights the potential for cannabidiol in the age of antimicrobial resistance.

    • Mark A. T. Blaskovich
    • , Angela M. Kavanagh
    • , Alysha G. Elliott
    • , Bing Zhang
    • , Soumya Ramu
    • , Maite Amado
    • , Gabrielle J. Lowe
    • , Alexandra O. Hinton
    • , Do Minh Thu Pham
    • , Johannes Zuegg
    • , Neil Beare
    • , Diana Quach
    • , Marc D. Sharp
    • , Joe Pogliano
    • , Ashleigh P. Rogers
    • , Dena Lyras
    • , Lendl Tan
    • , Nicholas P. West
    • , David W. Crawford
    • , Marnie L. Peterson
    • , Matthew Callahan
    •  & Michael Thurn
  • Article
    | Open Access

    Zarkali et al. identify two organizational gradients to structural-functional connectivity decoupling in Parkinson’s disease and relate spatial patterns of decoupling to the expression of neurotransmitter receptors. This study provides a framework that explains the specific disorders of consciousness in Parkinson’s dementia and its related neurotransmitter system.

    • Angeliki Zarkali
    • , Peter McColgan
    • , Louise-Ann Leyland
    • , Andrew J. Lees
    • , Geraint Rees
    •  & Rimona S. Weil
  • Article
    | Open Access

    Herdenberg et al. show that adipogenesis and BMP signaling are altered in mouse cells deficient in LRIG (Leucine-rich repeats and immunoglobulin-like domains) proteins. They find that mutant LRIG/sma-10 variant worms exhibit lipid storage defects and that human LRIG1 variants are associated with higher body mass index, yet protect against type 2 diabetes. This study suggests an evolutionarily conserved role of LRIG proteins for lipid metabolism and BMP signaling.

    • Carl Herdenberg
    • , Pascal M. Mutie
    • , Ola Billing
    • , Ahmad Abdullah
    • , Rona J. Strawbridge
    • , Ingrid Dahlman
    • , Simon Tuck
    • , Camilla Holmlund
    • , Peter Arner
    • , Roger Henriksson
    • , Paul W. Franks
    •  & Håkan Hedman
  • Article
    | Open Access

    Wenyan Nong, Zhe Qu, Yiqian Li, Tom Barton-Owen, Annette Wong and colleagues provide genomes and small RNA transcriptomes for the mangrove horseshoe crab and the tri-spine horseshoe crab. They show that horseshoe crabs have undergone three rounds of whole genome duplication and shed light on how gene families and microRNAS evolved following this genome duplication event.

    • Wenyan Nong
    • , Zhe Qu
    • , Yiqian Li
    • , Tom Barton-Owen
    • , Annette Y. P. Wong
    • , Ho Yin Yip
    • , Hoi Ting Lee
    • , Satya Narayana
    • , Tobias Baril
    • , Thomas Swale
    • , Jianquan Cao
    • , Ting Fung Chan
    • , Hoi Shan Kwan
    • , Sai Ming Ngai
    • , Gianni Panagiotou
    • , Pei-Yuan Qian
    • , Jian-Wen Qiu
    • , Kevin Y. Yip
    • , Noraznawati Ismail
    • , Siddhartha Pati
    • , Akbar John
    • , Stephen S. Tobe
    • , William G. Bendena
    • , Siu Gin Cheung
    • , Alexander Hayward
    •  & Jerome H. L. Hui
  • Article
    | Open Access

    Geng et al. evaluate bone marrow stem cell (BMSC)-based system to deliver modified RNAs of BMP-2 and VEGF to enhance bone regeneration. They test its therapeutic efficacy in vivo on a rat skull defect model by inoculating these BMSCs in a collagen scaffold. This construct synergistically drives osteogenic and angiogenic pathways and can be a new approach for clinical treatment of bone injuries and defects.

    • Yingnan Geng
    • , Huichuan Duan
    • , Liang Xu
    • , Nevin Witman
    • , Bingqian Yan
    • , Zheyuan Yu
    • , Huijing Wang
    • , Yao Tan
    • , Liqin Lin
    • , Dong Li
    • , Shanshan Bai
    • , Regina Fritsche-Danielson
    • , Jie Yuan
    • , Kenneth Chien
    • , Min Wei
    •  & Wei Fu
  • Article
    | Open Access

    Hwang et al. demonstrate that a high axial resolution can be achieved even with low numerical aperture (NA) objectives. They show the nano-profile of a basal cell membrane using metal-induced energy transfer and biexponential fluorescence lifetime analysis. The low-NA objective provides a larger field-of-view (FOV), thereby overcoming the limitations of a small FOV of the usually used high-NA objectives.

    • Wonsang Hwang
    • , Jinwon Seo
    • , DongEun Kim
    • , Chang Jun Lee
    • , In-Hong Choi
    • , Kyung-Hwa Yoo
    •  & Dug Young Kim
  • Article
    | Open Access

    Herberg et al. previously showed functional healing of femoral defects using scaffold-free human mesenchymal stem cell (hMSC) condensates with localized morphogen presentation. In this study, they report the importance of the tubular geometry of MSC condensates in long bone regeneration. Unlike loosely packed hMSC sheets, only hMSC tubes induced regenerate tissue partially resembling normal growth plate.

    • Samuel Herberg
    • , Daniel Varghai
    • , Daniel S. Alt
    • , Phuong N. Dang
    • , Honghyun Park
    • , Yuxuan Cheng
    • , Jung-Youn Shin
    • , Anna D. Dikina
    • , Joel D. Boerckel
    • , Marsha W. Rolle
    •  & Eben Alsberg
  • Article
    | Open Access

    Vacheron et al. visualize the dynamics of production, cellular transport and release of phage tail-like devices called R-tailocins by Pseudomonas bacteria and demonstrate their kin killing activity at single-cell level. The study offers insights into microbial competition mechanisms.

    • Jordan Vacheron
    • , Clara Margot Heiman
    •  & Christoph Keel
  • Article
    | Open Access

    Tajiri et al. describe how the cuticle coating the Drosophila larval body expands less efficiently along the body circumference than along the anteroposterior axis to drive body elongation. This “corset” property depends on cuticular proteins Cpr11A and Tubby, which may work together to change larval body shape.

    • Reiko Tajiri
    • , Haruhiko Fujiwara
    •  & Tetsuya Kojima
  • Article
    | Open Access

    Brandman et al compared fMRI coactivations and behavioral responses across participants who watched the same short movie. They demonstrated that the default mode network plays a central role in the representation of surprise – a process which is important for updating internal narrative representations

    • Talia Brandman
    • , Rafael Malach
    •  & Erez Simony
  • Article
    | Open Access

    Mechanosensitive Piezo1 channels transduce mechanical stimuli into electrochemical signals. Jiang et al. show that due to the bending rigidity of the membrane, the overlap of neighboring Piezo1 footprints produces a flattening of the Piezo1 footprints and a cation-selective conducting pore. This study suggests that the clustering of Piezo1 channels may tune its sensitivity to applied force.

    • Wenjuan Jiang
    • , John Smith Del Rosario
    • , Wesley Botello-Smith
    • , Siyuan Zhao
    • , Yi-chun Lin
    • , Han Zhang
    • , Jérôme Lacroix
    • , Tibor Rohacs
    •  & Yun Lyna Luo
  • Article
    | Open Access

    Zhang et al. use mouse tumor models to show that the optimum treatment regime for Treg-induced radiation resistance is vaccine administration followed by radiation therapy. This finding could inform the design of future combinatorial cancer therapies in the clinic.

    • Fayun Zhang
    • , Zifeng Zheng
    • , Apurba Kumar Barman
    • , Zihao Wang
    • , Luyao Wang
    • , Wenfeng Zeng
    • , Luoyang Wang
    • , Yan Qin
    • , Asmita Pandey
    • , Chunling Zhang
    •  & Wei Liang
  • Article
    | Open Access

    Phillip and colleagues use dermal fibroblasts from a range of donors to quantify cell motility in ageing cells. They show that the age-dependent decrease in cell motility is not due to the reduced motility of all cells, but results from the fractional redistribution among motility states.

    • Jude M. Phillip
    • , Nahuel Zamponi
    • , Madonna P. Phillip
    • , Jena Daya
    • , Shaun McGovern
    • , Wadsworth Williams
    • , Katherine Tschudi
    • , Hasini Jayatilaka
    • , Pei-Hsun Wu
    • , Jeremy Walston
    •  & Denis Wirtz
  • Article
    | Open Access

    Ha et al. present a crystal structure of mouse IRGB10, a mouse interferon-inducible GTPase that mediates bacteriolysis in cell autonomous immunity. With further mutagenesis studies, they show that IRGB10 bound to GDP forms an inactive head-to-head dimer, which changes its conformation to activate its membrane-binding and disruptive functions.

    • Hyun Ji Ha
    • , Hye Lin Chun
    • , So Yeon Lee
    • , Jae-Hee Jeong
    • , Yeon-Gil Kim
    •  & Hyun Ho Park
  • Article
    | Open Access

    Chowdhury et al. develop the Divider Assay, which is a simplified experimental procedure that allows Drosophila researchers to perform aggression analysis for a long period of time and in complete darkness. They find a peak in fighting during the middle of the day. This pipeline is expected to facilitate high-throughput screening for aggression.

    • Budhaditya Chowdhury
    • , Meng Wang
    • , Joshua P. Gnerer
    •  & Herman A. Dierick
  • Article
    | Open Access

    Van Lindt, Bratek-Skicki et al. show that at carefully selected pH values, proteins can be kept in solution and their LLPS can then be induced by a jump to native pH. This presents a generic method to study the full kinetic trajectory of LLPS under near native conditions that can be easily controlled, providing a platform for the characterization of physiologically relevant phase-separation behaviour of diverse proteins.

    • Joris Van Lindt
    • , Anna Bratek-Skicki
    • , Phuong N. Nguyen
    • , Donya Pakravan
    • , Luis F. Durán-Armenta
    • , Agnes Tantos
    • , Rita Pancsa
    • , Ludo Van Den Bosch
    • , Dominique Maes
    •  & Peter Tompa
  • Article
    | Open Access

    Raddatz, Lyko and colleagues use whole-genome bisulfite sequencing data to generate a methylation clock for chicken. This clock was able to detect age acceleration in broiler chickens under experimentally induced inflammation.

    • Günter Raddatz
    • , Ryan J. Arsenault
    • , Bridget Aylward
    • , Rose Whelan
    • , Florian Böhl
    •  & Frank Lyko
  • Article
    | Open Access

    Clare Gray et al. construct multilayer networks of weed seed regulation and pest gastropod predation by carabid beetles in 374 agricultural fields and show that these ecosystem services are mediated by trophic interaction frequencies. This study reveals that ecosystem services are governed by ecological plasticity in structurally complex, multi-layer trophic networks and these could assist in the assessment of the contribution of biodiversity to ecosystem services.

    • Clare Gray
    • , Athen Ma
    • , Orla McLaughlin
    • , Sandrine Petit
    • , Guy Woodward
    •  & David A. Bohan
  • Article
    | Open Access

    Olena Maiakovska et al. provide whole-genome sequencing of the parthenogenetic and invasive marbled crayfish and develop a computational framework for data analysis of monoclonal genomes. These data and methodology allow the authors to demonstrate genetic separation between two populations and provide the first size estimate for a marbled crayfish colony, which they used to model population growth patterns.

    • Olena Maiakovska
    • , Ranja Andriantsoa
    • , Sina Tönges
    • , Carine Legrand
    • , Julian Gutekunst
    • , Katharina Hanna
    • , Lucian Pârvulescu
    • , Roman Novitsky
    • , András Weiperth
    • , Arnold Sciberras
    • , Alan Deidun
    • , Fabio Ercoli
    • , Antonin Kouba
    •  & Frank Lyko
  • Article
    | Open Access

    Lenk et al find that the preB cell receptor (preBCR) is associated with infiltration and relapse of acute lymphoblastic leukemia in the central nervous system (CNS). They also show that downregulation of preBCR component CD79a reduces the engraftment of leukemia cells in different murine xenograft models, particularly in the CNS.

    • Lennart Lenk
    • , Michela Carlet
    • , Fotini Vogiatzi
    • , Lea Spory
    • , Dorothee Winterberg
    • , Antony Cousins
    • , Michaela Vossen-Gajcy
    • , Olta Ibruli
    • , Christian Vokuhl
    • , Gunnar Cario
    • , Omar El Ayoubi
    • , Lisa Kramer
    • , Matthias Ritgen
    • , Monika Brüggemann
    • , Robert Häsler
    • , Martin Schrappe
    • , Stephan Fuhrmann
    • , Christina Halsey
    • , Irmela Jeremias
    • , Elias Hobeika
    • , Hassan Jumaa
    • , Ameera Alsadeq
    •  & Denis M. Schewe
  • Article
    | Open Access

    Martins et al. examine the effects of different routes of administration of oxytocin on functional connections in the brain of healthy males at rest. They observe local effects in key-hubs of brain’s oxytocin system (i.e. amygdala) as well as wider-spread effects. This demonstrates that oxytocin likely affects human behaviour by modulating multiple levels of brain processing across different systems.

    • Daniel Martins
    • , Ottavia Dipasquale
    •  & Yannis Paloyelis
  • Article
    | Open Access

    Santos et al. demonstrate that the Near Infrared Spectroscopy (NIRS) can accurately estimate the death time of trapped female Aedes aegypti and vector infection with Zika virus, Chikungunya virus, or Wolbachia in a 7-day trapping period. This study suggests that NIRS may provide an accurate and inexpensive tool that improves arbovirus surveillance systems.

    • Lilha M. B. Santos
    • , Mathijs Mutsaers
    • , Gabriela A. Garcia
    • , Mariana R. David
    • , Márcio G. Pavan
    • , Martha T. Petersen
    • , Jessica Corrêa-Antônio
    • , Dinair Couto-Lima
    • , Louis Maes
    • , Floyd Dowell
    • , Anton Lord
    • , Maggy Sikulu-Lord
    •  & Rafael Maciel-de-Freitas
  • Article
    | Open Access

    Xiaoding Hu et al. find that expression of the proteoglycan decorin is decreased in patients with inflammatory breast cancer compared to normal breast tissue and some other types of breast cancer. They demonstrate that decorin acts as a tumor suppressor in cancer cells and human xenograft mouse models by destabilizing the E-cadherin-EGFR signaling axis, and their findings suggest potential therapeutic strategies for this aggressive breast cancer.

    • Xiaoding Hu
    • , Emilly S. Villodre
    • , Richard Larson
    • , Omar M. Rahal
    • , Xiaoping Wang
    • , Yun Gong
    • , Juhee Song
    • , Savitri Krishnamurthy
    • , Naoto T. Ueno
    • , Debu Tripathy
    • , Wendy A. Woodward
    •  & Bisrat G. Debeb
  • Article
    | Open Access

    Ayers et al. report rapid induction of apoptosis in the midgut of Aedes aegypti mosquitoes within 2 hours of infection by dengue and Zika viruses, and find that inhibiting apoptosis led to increased virus proliferation in the midgut. These results suggest rapid induction of apoptosis as an innate immune mechanism mediating midgut infection in this mosquito vector.

    • Jasmine B. Ayers
    • , Heather G. Coatsworth
    • , Seokyoung Kang
    • , Rhoel R. Dinglasan
    •  & Lei Zhou
  • Article
    | Open Access

    Jiahao Zhang, Kaixiong Ma, and Bo Li et al. identify a variant of the H9N2 avian influenza virus within the hemagglutinin cleavage site required for viral infection. They show that this variant leads to higher viral replication in cells and more virulent disease in both chickens and mice.

    • Jiahao Zhang
    • , Kaixiong Ma
    • , Bo Li
    • , Yiqun Chen
    • , Ziwen Qiu
    • , Jinchao Xing
    • , Jinyu Huang
    • , Chen Hu
    • , Yifan Huang
    • , Huanan Li
    • , Dingxiang Liu
    • , Ming Liao
    •  & Wenbao Qi
  • Article
    | Open Access

    Naylet Centeno-González et al. report the discovery of the oldest legume fruit fossil at 73.5 million years old in the Olmos Formation of Mexico. This finding supports the hypothesis that Mexico is the center of radiation for Fabaceae.

    • Naylet K. Centeno-González
    • , Hugo I. Martínez-Cabrera
    • , Héctor Porras-Múzquiz
    •  & Emilio Estrada-Ruiz
  • Article
    | Open Access

    Kiesow et al. use deep learning to identify partially overlapping subnetworks in the human social brain at the population level. They also demonstrate that the learned subnetwork representations can be used to predict social traits.

    • Hannah Kiesow
    • , R. Nathan Spreng
    • , Avram J. Holmes
    • , M. Mallar Chakravarty
    • , Andre F. Marquand
    • , B. T. Thomas Yeo
    •  & Danilo Bzdok
  • Article
    | Open Access

    Li et al. use experimental observations of red-nose tetrafish and mathematical simulations to model the burst-and-coast swimming regime. This study shows that in order to sustain the necessary speed, fish adopt a unique intrinsic cycle by modifying the burst to coast ratio and can implement this pattern at a range of swimming speeds.

    • Gen Li
    • , Intesaaf Ashraf
    • , Bill François
    • , Dmitry Kolomenskiy
    • , Frédéric Lechenault
    • , Ramiro Godoy-Diana
    •  & Benjamin Thiria
  • Article
    | Open Access

    Laura Jones et al. compare honey samples across the UK from 2017 to a nationwide survey of honey samples from 1952 in order to determine how nectar and pollen sources have changed over time. They find that shifts in major plants foraged by honeybees are driven by changes in the availability of these plants within the landscape, and focus on improved grasslands as the most widespread habitat type and a potential target for management efforts to increase floral resource availability.

    • Laura Jones
    • , Georgina L. Brennan
    • , Abigail Lowe
    • , Simon Creer
    • , Col R. Ford
    •  & Natasha de Vere
  • Article
    | Open Access

    Cover et al. develop a method that permits functional MRI of brain dynamics while mice are cued to perform an operant task: licking a spout to receive optogenetic stimulation to the medial prefrontal cortex. This method presents noninvasive whole brain readout for adaptive behavior of mice in response to circuit-specific neuromodulation.

    • Christopher G. Cover
    • , Andrew J. Kesner
    • , Shehzad Ukani
    • , Elliot A. Stein
    • , Satoshi Ikemoto
    • , Yihong Yang
    •  & Hanbing Lu
  • Article
    | Open Access

    Guillaume Peterson St-Laurent et al. introduce the R–R-T (Resistance-Resilience-Transformation) conservation typology that enables the empirical assessment of whether and to what extent a management shift toward transformative action is occurring. They apply the R–R-T scale to 104 adaptation projects and find a shift towards transformation over time and differential responses across ecosystems, with more transformative actions applied in forested ecosystems.

    • Guillaume Peterson St-Laurent
    • , Lauren E. Oakes
    • , Molly Cross
    •  & Shannon Hagerman
  • Article
    | Open Access

    With fluorescence based-TIRF microspectroscopy, Ušaj et al. unveil mechanistic details about the ATP turnover rates by myosin and actomyosin with enzymatic reaction pathways that were not possible to obtain from ensemble studies. This study could be important to the field of molecular motors.

    • Marko Ušaj
    • , Luisa Moretto
    • , Venukumar Vemula
    • , Aseem Salhotra
    •  & Alf Månsson
  • Article
    | Open Access

    Spagnolli, Massignan, Astolfi et al. design a new drug discovery approach, termed Pharmacological Protein Inactivation by Folding Intermediate Targeting, in which folding intermediates of disease-causing proteins are targeted. They test it on the cellular prion protein, identifying ligands stabilizing a folding intermediate and consequently promoting its degradation by the cellular quality control machinery.

    • Giovanni Spagnolli
    • , Tania Massignan
    • , Andrea Astolfi
    • , Silvia Biggi
    • , Marta Rigoli
    • , Paolo Brunelli
    • , Michela Libergoli
    • , Alan Ianeselli
    • , Simone Orioli
    • , Alberto Boldrini
    • , Luca Terruzzi
    • , Valerio Bonaldo
    • , Giulia Maietta
    • , Nuria L. Lorenzo
    • , Leticia C. Fernandez
    • , Yaiza B. Codeseira
    • , Laura Tosatto
    • , Luise Linsenmeier
    • , Beatrice Vignoli
    • , Gianluca Petris
    • , Dino Gasparotto
    • , Maria Pennuto
    • , Graziano Guella
    • , Marco Canossa
    • , Hermann C. Altmeppen
    • , Graziano Lolli
    • , Stefano Biressi
    • , Manuel M. Pastor
    • , Jesús R. Requena
    • , Ines Mancini
    • , Maria L. Barreca
    • , Pietro Faccioli
    •  & Emiliano Biasini
  • Article
    | Open Access

    Here, the authors introduce a metabolome-wide association study that combines a genome-wide association study of cerebrospinal fluid metabolites with publicly available genome-wide association study summary statistics of neurological and psychiatric conditions to identify 19 significant CSF metabolite-phenotype associations.

    • Daniel J. Panyard
    • , Kyeong Mo Kim
    • , Burcu F. Darst
    • , Yuetiva K. Deming
    • , Xiaoyuan Zhong
    • , Yuchang Wu
    • , Hyunseung Kang
    • , Cynthia M. Carlsson
    • , Sterling C. Johnson
    • , Sanjay Asthana
    • , Corinne D. Engelman
    •  & Qiongshi Lu
  • Article
    | Open Access

    Geis et al. investigate the potential application of hemibodies, a pair of complementary antibody fragments that redirect T cells against cancer-defining antigen combinations, such as CD38 and SLAMF7, to target multiple myeloma. Their study provides evidence that hemibodies can be developed for effective immunotherapy against multiple myeloma.

    • Maria Geis
    • , Boris Nowotny
    • , Marc-Dominic Bohn
    • , Dina Kouhestani
    • , Hermann Einsele
    • , Thomas Bumm
    •  & Gernot Stuhler
  • Article
    | Open Access

    Mukherjee, Nandekar and Wade investigate the structural arrangement of the complex between membrane-bound cytochrome P450 1A1 and NADPH-cytochrome P450 reductase. They find that upon binding to the reductase, the catalytic domain of cytochrome P450 1A1 reorients subject to the constraints of membrane binding, potentially explaining why the electron transfer rates between the proteins are low when compared to those of soluble bacterial cytochrome P450s.

    • Goutam Mukherjee
    • , Prajwal P. Nandekar
    •  & Rebecca C. Wade