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Brain-derived endothelial cells transplanted into a mouse chronic cerebral hypoperfusion model showed excellent angiogenic potential and were also associated with reducing both white matter lesions and brain dysfunction possibly due to the high expression of neuroprotective humoral factors.
A signal transmission strategy, based on the cooperative activities of Exonuclease III and Exonuclease lambda enzymes, generates discrete and tightly amplified DNA signals that overcome signal attenuation and resolve the polarity of signals and byproducts.
Deep investigation of the sequence-structure-function landscape of the tetracycline destructase family of antibiotic resistance enzymes identifies new enzymes, and amino acid spositions essential to activity.
The no-reflow phenomenon after stroke is attributed to damaged spontaneous vasomotion of cerebral arterioles, which can be alleviated by maintaining mitochondria-ER contact-dependent Ca2+ oscillation.
Omicron variants BQ.1.1 and XBB increased pathogenicity in wild-type hamsters, with BQ.1.1 showing higher mortality in human ACE2 transgenic hamsters compared to earlier Omicron variants..
This study identified a cross-hemispheric anterior cingulate arc via the claustrum which allows the brain to allocate attentional priority to competing innocuous and noxious inputs by activating fast-spiking interneurons.
Microphone data from Greenland suggest that a colony of a key Arctic-breeding seabird, the little auk, bursts with acoustic excitement at night, under the midnight sun. The study highlights that acoustics is a promising monitoring tool.
Using metabarcoding, we found that seasonal dietary shifts were associated with slower breeding and acacia are fallback foods for black rhino. Grass was the highest value food for Grevy’s zebra. Seasonal diet shifts did not drive microbiome shifts.
Two membrane curvature-sensitive motifs in unstructured regions of the N-terminal domain of VPS37A are required for its phagophore recruitment and autophagosome closure.
An analysis of leaf disparity through time in cycads shows that this group has a dynamic and expanding morphological diversity until the present, and thus does not fit the ‘living fossil’ hypothesis often associated with them.
A novel device for selective large-scale optogenetic manipulation of the deep layers of cortical circuits in non-human primates is presented and validated using electrophysiological recordings and c-fos imaging in macaque visual cortex.
An integrated framework to identify immune checkpoint-related lncRNA core regulatory circuitry triplets has the potential to improve our understanding of lncRNA functions and accelerate the discovery of lncRNA-based biomarkers for immune checkpoint inhibitor treatment.
A neural network model built on stage-specific gene expression data suggests an attractor-based dynamical explanation for the temporal stability of multipotent cell states and signal-driven lineage commitment.
Whole-genome analysis of 876 Aspergillus fumigatus strains including 171 strains from Japan highlights the diversity in the A. fumigatus strains isolated in Japan as well as the complexity in the global distribution of the pathogenic strains.
The authors present a method utilizing the reversible protein tag ProMTag to prepare high-quality, sequencing-ready DNA and RNA, and either intact proteins or mass spectrometry-ready peptides for whole proteome analysis from a single sample.
ATLAS is a pair of AI Tumor Lineage and Site-of-origin machine learning models, that can accurately classify both primary and metastatic tumors using high-throughput RNA expression data and can identify de-differentiated anaplastic tumors.
The authors classify 293 ligand binding sites from 37 proteins into four groups by their solvent accessibility profile. The groups differ in evolutionary conservation and functional enrichment, and can be predicted by a machine learning model.
A deep learning model—OrgaSegment—is presented for segmentation of individual intestinal patient-derived organoid structures from bright-field images. This enables quantification of organoid swelling and discrimination between organoids with different levels CFTR function and response to therapy.