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The methyltransferase TrSAM from Trichoderma reesei is suggested to have an important role in regulating the expression of cellulase and heterologous proteins initiated by cbh1 promotor through interacting with ACE1R383.
Pan-cancer analysis of kindlin genes on patient genomic data reveals a distinct pattern of kindlin activity. Our analysis suggests kindlins as mechanochemical connector of major cancer hallmark pathways.
A study of opportunity on deep-sea Ridge Flank Hydrothermal Systems, which host low-temperature, chemically insignificant venting, suggests that warmer temperatures are a contributing factor to changing community composition and higher biodiversity.
An epigenetic study on free-ranging spotted hyenas (Crocuta crocuta) suggests that genes are differentially methylated between high-ranking and low-ranking females (cubs and adults) which may reflect rank-specific differences in access to resources.
We present a new method for the efficient segmentation and 3D shape analysis of mitochondrial inner components from FIBSEM images using multiplanar UNET and persistent homology.
Expanded intronic G4C2 repeats in C9orf72 cause ALS/FTD. GR dipeptide repeats produced in C9orf72 ALS/FTD co-aggregate with Kap2 in neurons, affecting survival. Upregulating Kapβ2 may mitigate neurotoxicity, a potential therapy for C9orf72-ALS/FTD.
The long-read metagenome of rice phyllosphere microbiome shows novel complete chromosomes, plasmids, bacteriophages, and novel bacterial species. Notably one complete chromosome belongs to the difficult-to-culture bacterium CandidatusSaccharibacteria.
Osteoarthritis (OA) affects over 500 million adults worldwide. Signal transducer and activator of transcription 1 can increase complement C3 expression after IL-1β stimulation, and STAT1 inhibition can prevent OA pathogenesis in guinea pigs.
Both PKC phosphorylation and elevated calcium levels are required for TRPM5 activation, the phosphorylation is crucial for channel-evoked currents at physiological membrane potentials.
Mutational analysis of the flagellar export apparatus protein FlhA suggests that the conserved GYXLI motif of FlhA, together with the cytoplasmic ATPase complex, strictly regulate the order of flagellar protein export.
Aerodynamic modeling based on the primitive, early Eocene bat Onychonycteris strongly supports a gliding transition to powered flight in mammals, which is facilitated under the hyperdense atmospheric conditions here inferred for the fossil age.
The promoter PSCBV-YZ2060 cloned from the sugarcane bacilliform virus is shown to be induced by drought in sugarcane and Arabidopsis plants and is a potential alternative promoter for genetic engineering of drought-resistant transgenic crops.
Nutrition shapes animal growth and survival. E. coli-derived vitamin B6 is crucial for reversing developmental arrest in C. elegans fed with probiotic Lactiplantibacillus plantarum, independently of FoxO/DAF-16 activation.
Analysis of M3-Gq coupling utilized fulllength proteins and techniques like HDX-MS & NanoBiT assay, revealing potential binding interfaces in the preassembled and agonistactive complexes and critical regions for the complex formation and Gq activation.
Maternal RNA transcription plays an important role in maintaining vasculature in mouse placental development, associated with regulating gene expression, imprinting status and DNA methylation in the Dlk1-Dio3 imprinted domain.
The output of a nanomachine powered by an array of myosin molecules purified from the skeletal muscle is fed to a stochastic model, which provides a self-consistent estimate of all the mechanokinetic parameters of the motor ensemble.
By combining different microscopy techniques, olive leaf surfaces are shown to be chemically heterogeneous due to the occurrence of trichomes which have mixed hydrophilic-hydrophobic areas at the nanoscale level.
A modelling framework characterising the dynamics of Plasmodium vivax lactate dehydrogenase provides estimates of key biological parameters to facilitate the development of improved diagnostic tools for the detection of P. vivax.
A genetic mouse model of lean-NAFLD reveals that male exhibit a more severe hepatic phenotype with increased macrophage infiltration, FGF21 concentration and sustained hypoglycemia associated with cardiac diastolic dysfunction.
The analysis of root fungal, mycorrhizal, and bacterial communities of tree seedlings sampled across elevation gradients reveals strong effects of edaphic factors on microbial communities and interactions between root microbes and seedling growth.