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A unique soluble β-carotene-binding protein pigment extracted from yellow locust cuticle is biochemically and spectroscopically equivalent to the protein reconstituted in carotenoid-producing E. coli cells and capable of binding to chitin in vitro.
In Zebrafish embryos spinal cords, neural precursors are clustered in two distinct populations based on their spindle-microtubule enrichment. KIF16Ba, CAMSAP2a/3a and spindle-microtubule enrichment control Sara endosome motility and mediate neural precursor fates.
Generation of an endogenous Cyp1a1 luciferase reporter mouse model to dynamically and longitudinally visualize AHR activity throughout lifespan and in response to ligand exposure, reveals prolonged AHR activation in the lung.
A genetic study that explores the relationship between risk behaviours engagement in adolescents and educational achievement. This study found that risk behaviours were phenotypically associated with educational achievement at age 16, even after adjusting for confounders.
Finite element analysis shows distinctive strengthened cranial biomechanics in Oviraptorosauria compared with other herbivorous theropod dinosaurs, established prior to the highly modified oviraptorid cranial morphology.
Multiscale molecular dynamics simulations reveal rapidly exchanging lipid binding sites on the nicotinic acetylcholine receptor, including sites with high affinity for phosphatidic acid and promiscuous cholesterol sites in inter-α-helix grooves.
A large-scale study in Europe elucidating the contribution of pathogen clade and host species in disease hotspots caused by Ophidiomyces ophidiicola, the pathogen responsible for snake fungal disease.
Pioneering coral probiotics study shows in situ application reshapes the coral microbiome, boosting beneficial bacteria and reducing pathogens without affecting surrounding seawater and sediment microbiomes.
Targeted modifications of NAD(H) pool size reveal NADH FLIM is sensitive to changes in NAD(H) pool size, mimicking the effect of redox alterations. This potentially confounds experiments where changes to both modalities occur, such as with aging.
A study in mice to identify mechanisms through which a mucosal Klebsiella pneumoniae vaccine elicits Th17 tissue resident memory cells in the lungs reveals a major role for IL-1a signaling and highlights the utility of IL-1a as a mucosal adjuvant.
Hypertension, and organ system dysfunctions associated with preeclampsia (PE) result in poor pregnancy outcomes. In the current study, the authors examined molecular pathogenesis of PE with a focus Peroxisome proliferator-activated receptor gamma (PPARγ), lipid metabolism, and ferroptosis in the placenta of PE patients.
Pancreatic cancer-associated fibroblast enhance the expression of sialic acidcontaining glycans, which interact with Siglec7, -9, -10, -15 receptors on myeloid cells, and drive the differentiation to immunosuppressive macrophages.
Analysis of the virus community associated with red algal mats in Yellowstone National Park shows it to be dominated by Megaviricetes, with resident virus lineages being of ancient origin and encoding genomic footprints of adaptation to thermophily.
Molecular changes in neurodegeneration occur much earlier than previously expected. In this study, dynamic molecular network analysis of iPSC differentiation uncovers a temporal pathway from histone to ISG15 with the earliest molecular changes of SCA1.
A genome-wide association study of 57 trace elements measured in up to 6564 Scandinavians, identifies genetic loci associated with blood levels of essential and non-essential trace elements and explores their effects on health outcomes.
A functional genomics approach in patient derived cell lines of Favorable Histology Wilms Tumor identifies suppression of TRIP13 through the nuclear export inhibitor, KPT-330, leads to decreased viability and synergy with doxorubicin.
A Klebsiella pneumoniae peptide enters Streptococcus pneumoniae via its AmiA-AliA/AliB permease reducing pneumococcal growth, adherence to primary human airway epithelial cells, colonization of rat nasopharynx and genetic transformation.
The cytogenetic analysis of gonial cells and meiocytes on Korean loach complex suggest that instant switch between sexual to asexual reproduction in hybrids depend on their ploidy and genome dosage.