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In this Perspective, the authors evaluate the evidence for sexual selection on communication across Animalia, with particular emphasis on chemosensory traits.
A comprehensive multi-omic, single-cell, and spatial analysis provides further insight into the major cell types present in three types of primary liver cancer.
Therapeutic administration of highly selective ROCK2 inhibitor reverses established liver fibrosis induced by chemical injury combined with high fat diet in mice via concurrent targeting of inflammatory, fibrotic and metabolic cellular pathways
Expression of the oncoprotein TAZ::CAMTA1 leads to hypertranscription and considerable DNA damage. As TAZ::CAMTA1-expressing cells have impaired homologous recombination, the DNA damage remains unrepaired and the cells enter senescence.
Ex vivo imaging of eccrine sweat glands suggests that cholinergic stimuli trigger segmental contraction of myoepithelial cells through gap junction-mediated intercellular communication and facilitate peristaltic sweat secretion.
Here, through progressive structural optimization, two “tadpole-like” antimicrobial peptides are constructed with an amphipathic α-helical head and an aromatic tail activity. These exhibit potent antimicrobial activity, no hemolytic activity and cytotoxicity, and no propensity to induce resistance.
Wnt/β-catenin signalling activation in the dermis cause fibrosis by cell-autonomous program and by a non-cell-autonomous program mediated by TGF-β niche formation based on Cxcl14-mediated interactions between stromal cells and M2 macrophages.
A large collection of single-gene deletion mutants was screened to identify specific LPS structures recognized by specialized adhesins found in a type IV pilus encoded by conjugative plasmid TP114 to enable high transfer rates in fluids.
A pan-cancer machine learning model using epifactor expression data for five cancer types and single-cell analysis of adult and pediatric tumors reveal expression patterns associated with poor or worse outcomes are present in individual cells within tumors.
A quantitative analysis of mite symbionts of a brood parasitic passerine bird indicates that conspecific horizontal transmission plays a key role in host colonization and it can also promote codiversification at the macroevolutionary scale.
The study shows, by using hematopoietic chimeric mice, that mucosal immune cell-derived enkephalins play a pivotal role in maintaining gut homeostasis including visceral sensitivity and normal behavior in mice.
In situ tissue engineered heart valve prostheses implanted in aortic position of an ovine model up to 12 months meet several hallmarks for sustainable heart valves prostheses, but variability in tissue remodelling and valve functionality are seen.
Based on the phenotypic response of Escherichia coli cells to antibiotic treatment, a deep-learning approach could rapidly distinguish susceptible and resistant cells from fluorescence microscopy images.
Advanced imaging and electrophysiology show that phosphorylation boosts the size of KV2.1 clusters, which in turn modulates dihydropyridine-sensitive CaV1.2 channel organization and function in arterial smooth muscle, with variations based on sex.
A virtual reality study suggests that multisensory input shifts computations to extrahippocampal regions that support spatial navigation, as multisensory input improves memory-guided spatial navigation in humans with and without hippocampal lesions.
Prion aggregate complexity affects prion biochemical properties, neuropathology, and clinical signs upon infection of mice. Aggregate size-specific clinical signs are retained upon passage despite convergence of prion properties.
An fMRI study on the neural mechanisms by which the human brain may integrate semantic and mechanical knowledge to understand tool-related actions. The study underscores the key roles of the left inferior parietal and anterior temporal lobes in physical/conceptual processing, respectively.
Mendelian randomization analysis leveraging data from the UK Biobank and 23andMe, Inc., suggests that an individual’s sleep habits may impact those of their partner.