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Prodromal gut inflammation exacerbates Parkinson’s disease endophenotypes in mouse carriers of human LRRK2 G2019S in a sex-dependent manner, showing increased α-synuclein positive macrophages in the colon and brain microglia.
This study on how Staphylococcus aureus manipulates host-derived fatty acids reveals that a bacteriallipase (Lip2) converts toxic fatty acids and cholesterol into innocuous cholesteryl esters.
An in vitro and in vivo study using human melanoma cell lines suggests that perturbing lysosomal function stimulates lysosome biogenesis and decreases invasiveness potential.
A computational study describing a parallel extension to software “STochastic Engine for Pathway Simulation" that simulates vesicles and their interactions with the cellular environment, including endocytosis, docking, fusion and active transport.
A study found that circFOXP1 was highly expressed in gastric cancer (GC) and demonstrated that ALKBH5-mediated m6A modification of circFOXP1 promoted GC progression by regulating SOX4 expression and sponging miR-338-3p.
A high-resolution structure provides a mechanistic explanation to the synthetic selectivity of quinolone synthase (AmQNS) and possible consequences of functionally relevant residue mutations.
Using multi-isotope analysis of tooth enamel of reindeer, equids and mammoth from the archaeological sites of Königsaue and Breitenbach, the authors identify shifts in ranging behaviour of these hominin prey species during the Last Glacial Period in Central Germany.
EP4 receptor enhances OSCC cell migration through increased Ca2+ signaling, linking to CALML6 and the CaMKK2 pathway. This process promotes mitochondrial function and metastasis, with CaMKK2 emerging as a potential target for OSCC treatment.
This study shows that the soil microbial community and herbivory both influence the assembly of the plant-associated microbial communities, but their effects are generated through different mechanisms.
An orally available VHL-ERα PROTAC was developed that showed excellent degradation in vitro. When dosing in vivo, the degradation of ERα was lower than expected, due to competitive binding at the ERα binding site between the PROTAC and a linker metabolite.
An NMR study on the SIB1-WRKY33 interaction identifies the minimal sequence in SIB1 that is essential for complex formation and provides a structural model for understanding how SIB1 regulates the DNA binding activity of WRKY33.
Cryptophyte PSI-CAC structures revealed the differences in protein composition and CAC organization of PSI complex in exponential and stationary growth phases, which might be involved in the binding and energy transfer of lumenal phycobiliproteins.
A field study of coinfection prevalence in water fleas populations revealed strong temporal pattern with prevalence level that don’t differ from random chance, suggests that coinfections in these populations governed by parasite diversity.
MSCs-exo-mediated delivery of miR-1403p ameliorates cognitive impairment in mice with SAE by HMGB1-related microglial pyroptosis and S-lactoylglutathione metabolism.
Developmental changes from birth to 5-years in ASD were associated with a normal physiologic response to chronic excitatory, ATP-related signaling. An inhibitory reversal in this network occurred during typical development that did not occur in ASD.
Piperidine-based ionizable lipids avoid the formation of mRNA–lipid adduct that is responsible for the loss-of-function of mRNA and contribute to the long-term storage stability of mRNA/LNPs as a wet preparation.
This integrative structural biology study elucidates the architecture of the L-A virus at the highest resolution reported to-date. The employed methodology to study yeast cell extracts with minimum perturbation allows exploring protein interactions involved in endogenous virus assembly and function.
Using two-photon fluorescence imaging, the authors show that superoxide anion in hepatic stellate cells impairs the infiltration of CD8+ T cells in a mouse model of hepatocellular carcinoma.
Mathematical models and computer simulations suggest that anti-Hebbian STDP, the type of plasticity observed between cortex and striatum, could support the learning of sequences in the brain.