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The first X-ray crystal structure of a hetero-tetrameric septin complex is presented. From this a novel hydrophobic structural element conserved in septins from yeast to man is identified and characterized.
This study reveals that the proinflammatory chemokine CXCL14 activates MAS-related G protein-coupled receptor MRGPRX2; these results provide a rational basis for the future development of idiopathic pulmonary fibrosis therapies.
New protocols allow the collection of fluorescence excitation and emission spectra from a variety of fluorescent plant megafossils, enabling research into the underlying fluorescent molecules, including potential remnants of original fluorescence.
STEM is a transfer-learning-based method that integrates spatial transcriptomics and scRNA-seq data to reconstruct localization at the single-cell level and reveal gene expression variation within cell types in tissues.
Mendelian randomization and colocalization analyses identified 13 circulating proteins causally associated with age at menarche and 7 proteins associated with age at natural menopause, highlighting the proteomic signatures encompassing both ends of women’s reproductive lifespans.
The σE regulon of Streptomyces coelicolor was determined in normal and ethanol treated conditions. Results of kinetic modeling, ChIP-seq and promoter mutagenesis suggested that σE can act both as a direct activator and repressor of transcription.
A multi-pronged activation approach applied to 54 actinobacterial strains doubles accessible metabolite space and enables discovery of gram-negative bioactivity, offering insights to harness nature’s chemical potential. The approach enhances or triggers natural product production across all 54 native actinobacterial strains, doubling total metabolite production and enabling the discovery of a new tetramic acid analog with gram-negative bioactivity. Insights from this large-scale study could lead to a more streamlined approach to unlock the full potential of nature’s chemical resources.
A combined treatment approach that targets both skin tumor cells and macrophages prevents tumor growth in malignant melanoma and squamous cell carcinoma.
A large-scale Passive Acoustic Monitoring of the vibroscapes on the forest floor suggests that ground-dwelling spiders may evolve behavioral strategies to avoid acoustic niche overlap with their sister species.
The mitochondrial protease PARL is essential for male fertility in mice, and knockout of PARL leads to an arrest in spermatogenesis due to downregulation of respiratory chain complex IV proteins in the testes and a deficit in ATP production there.
A biomechanical study on the attachment performance of seal lice suggests that the lice use modified snap hook claws and soft pad-like structures to generate exceptionally high attachment forces on the surface of their hosts.
The 4Ig isoform of B7-H3, an immune modulatory protein expressed in tumors, resides in dimeric states with enhanced dimerization-dependent intrinsic signaling and tumorigenic activities, providing a therapeutically-actionable target for intervention.
A study on metabolic markers in urine from Eastern bent-winged bats demonstrates seasonal and individual variations in water-stress that suggest an association between water-stress and winter arousal.
A study of 4,645 children in four countries in East Africa, 800 with Burkitt lymphoma (BL), identifies an association between HLA-DQA1*04:01 and variant rs2040406(G) and elevated risk of BL in Africa.
A large multi-ancestry genome-wide meta-analysis identifies novel basal cell carcinoma loci and shared genetic effects with squamous cell carcinoma, providing insight into the genetic basis of these serious forms of cancer.
An epigenome-wide association study of dementia with Lewy bodies discovers differentially methylated probes, genomic regions and pathways associated with this disease.
Genetic interaction studies in zebrafish larvae using hypomorphic alleles of dnmt1 and pole1 indicate that impaired DNA replication is associated with increased levels of post-replicative DNA methylation.
A solid-state NMR study on the ABC transporter MsbA demonstrates the interplay between transmembrane- and nucleotide-binding domains via both coupling helices.
A study using photoreceptor-specific knockout mice finds that SNAP-25, and not SNAP-23, is the isoform crucial for photoreceptor development, survival, and function. Mechanistically, SNAP-25 mediates photopigment trafficking and synaptic functioning.