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Microbial connectivity analysis of Arctic, subarctic, and temperate fjords revealed regionally distinct communities. Across regions, prokaryotes were more connected than picoeukaryotes, but their dispersal was limited by temperature barriers.
Structural analysis and molecular dynamics of the RAF1-HSP90-CDC37 and HSP90 complexes reveal asymmetric binding of RAF1 to HSP90, a bridging role for CDC37, HSP90’s structural rearrangements, and interactions of HSP90 with unfolded regions of RAF1.
An evolutional and functional study on bug saliva suggests that horizontally transferred genes provide a selective advantage to recipient insects by enhancing their feeding abilities.
A metabolomics study pioneers the evaluation of non-volatile compounds in the human ‘breathome’, identifying over 1000 metabolites and unveiling gender-specific metabolic patterns, thereby laying a foundation for investigating clinical biomarkers.
Winged, autorotating seeds from the genus Acer can autorotate despite significant morphological alteration, enduring mass changes >% while maintaining descent velocity changes of <%. A classical aerodynamic model well predicts descent velocity.
BRET-based biosensors allow the quantitative live-cell monitoring of RTKmediated signaling, revealing ligand-specific spatiotemporal and mutation-specific signaling biases, advancing the understanding of RTK functional selectivity.
An investigation of tau’s phase separation propensity and interactions with DNA, nucleosome arrays, and heterochromatin proteins shows that these properties are dependent on tau’s phosphorylation state.
Flatfish eye migration in metamorphosis study shows up-regulated immune genes. The process involves roles of myosin/ependymin, the link of alx3’s to cranial restructuring, changes in opsins adaptation to low light and an asynchronous system activation.
The crystal structure of a bacterial NAMPT with high enzymatic activity reveals a novel NAM-binding tunnel, which is essential for both catalysis and inhibitor binding. The binding of NAM in the tunnel positively cooperates with the catalytic site.
Various carriers are involved in extracellular Wnt transport. Here, the authors show that Wnt heterodimerization with its carrier protein, sFRP2, enhances Wnt accumulation on the cell surface, leading to exosome-mediated Wnt re-secretion.
Digital RNA sequencing using unique molecular identifiers and well-performing reverse transcription allows detection of mutant allele frequencies < 0.1%.
A study on bladder cancer indicates that Parkin influences bladder cancer progression and metastasis by regulating cellular ROS levels through ubiquitin-mediated proteasomal degradation of Catalase, rather than its autophagic function.
A microsensor study on a reef coral suggests that the photosynthetic activity of symbiotic dinoflagellates, lining the cœlenteron, contributes to changes in the cœlenteric fluid chemistry in response to light and spatial variability.
This transgenic mouse study based on different protein levels of the ISWI ATPase SMARCA5 shows accumulation of multipotent hematopoietic progenitors with block of B and T lymphopoiesis and, to a lesser extent, erythropoiesis at low SMARCA5 levels.
A study investigating the relationships among the gut microbiota, autonomic nervous system function, physical condition, and psychological state in Japanese mothers shows that high parenting stress results in microbial dysbiosis and increased intestinal inflammation.
A canonical circadian clock component in C. elegans was identified after decades of research: mammalian Ror homolog, nhr-23. It is essential for both the 8-h developmental rhythm and 24-h circadian rhythm.
This study establishes a previously unavailable protocol to derive phrenic-like motor neurons from human induced pluripotent stem cells, providing a system to study mechanisms of respiratory motor neuron dysfunction in Amyotrophic Lateral Sclerosis.
Biophysical analyses based on the crystal structure of PHD2 in complex with HIF2α peptide show that the strength of the interaction between Pacak-Zhuang syndrome-causing HIF2α mutants and PHD2 correlates with disease severity.
Development of platform to integrate multiple Tissue-in-a-CUBEs in a chip for tissue-tissue interaction, demonstrated by simulating the testing of the permeability and effect of a cancer drug in a BBB-Brain cancer model.