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The CYR1 mutation can enhance a strain’s thermotolerance and ability to produce high yields of recombinant protein by simultaneously strengthening stress resistance and the energy system through cAMP signalling cascades.
Partially reprogramming a specific population of neurons in the cerebral cortex of mice, improves cognition through greater activation in memory circuits and plasticity induced by the reorganization of the extracellular matrix.
The authors develop a web resource to present pan-cancer mutations in 32 major types of cancer. This new online somatic mutations atlas, OncoDB is publicly available at https://oncodb.org.
fMCI experiments on soft PDMS surfaces and mathematical models suggest that – in the low MPa range – increasing material compliance boosts neuron adhesion, clustering, and communication, impacting tissue engineering and regenerative medicine.
Using metabolomics and proteomics data, the quantity and composition of cellular lipid underwent notable changes in different eff Th cell subsets. Especially, Th17 and iTreg cells enhance glycosphingolipid metabolism to sustain their differentiation.
This study reports a unexpected role in endothelial cells (ECs) for PCK2 in proteostasis, independent of its gluconeogenic activity. Perturbation of this role likely contributed to the angiogenic defects observed in ECs with reduced PCK2 levels.
Activation of the Nrf2/HO-1 antioxidant signaling pathway exacerbates cholestatic liver injury due to excessive accumulation of bilirubin, rather than exerting a protective effect as in non-cholestatic liver injury.
A DADA2 zebrafish model with cecr1b deficiency was generated. Characterization of hematopoietic processes revealed a role of Cecr1b in regulating inflammation and hematopoietic stem cell production through the A2br-mediated adenosine signaling.
This study illustrates consistent declines in shark functional richness which corresponds with declining ecological functioning and a community shift from targeted apex sharks to a greater functional richness of non-target species.
Single nucleus RNA-seq and spatial transcriptomics reveal a detailed picture of the cichlid fish forebrain. Comparisons with atlases in other vertebrates uncover striking transcriptional similarities and lend new insights into forebrain evolution.
A study on a soybean DNA demethylase reveals that seed size is negatively regulated by GmDMEa, which is closely linked to methylation on transposon elements.
An fMRI study using a new navigation task suggests that state inference with multi-layered uncertainty engages different areas of the medial prefrontal cortex and basal ganglia, depending on its level in the hierarchy and the nature of inference.
AlphaFold structure predictions uncover an unexpected connectedness between prokaryotic membrane transport proteins and two-component sensory kinases, thereby defining a large “transceptor” class of membrane proteins that have crossed the border between transporters and receptors.
Using primary mouse model of soft-tissue sarcoma (STS), authors show that sarcoma switches to glutamine metabolism post radiation therapy, and inhibition of glutaminolysis, either via genetic or pharmacological alterations, radiosensitizes STS in vivo.
Skeletal muscle-specific GDE5/Gpcpd1 deletion leads to glycerophosphocholine accumulation, which alters skeletal muscle phospholipid profiles and reduces passive force in electrically stimulated skeletal muscles in vivo.
A GWAS on 500 genetically diverse rice accessions enables identification of an allelic series for the unusual Ptr rice blast resistance gene, and the Pia resistance locus.
QUINT workflow analysis of cell and amyloid density in AD-BXD mice demonstrates age-dependent and strain-specific increases in gliosis and amyloid accumulation. These changes in brain composition influence age-related variations in gene expression.