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A genome-wide association study in the China Kadoorie Biobank identified four novel loci related to snoring, and highlights the relevance of cardiometabolic health to snoring prevention.
ADAMTS4 is crucial for VCAN cleavage in the amnion at parturition, which participates not only in extracellular matrix remodeling but also in inflammatory reactions of the fetal membranes.
A brain stimulation study (tDCS) on healthy humans shows that the medial prefrontal cortex plays a causal role in learning social hierarchical relationships by observation.
A comprehensive study reveals that the two-component system BfmRS senses high osmotic stress and transcriptionally activates the expression of siderophore genes, which is essential for environmental adaption of P. aeruginosa.
The microRNA miR-221-3p inhibits the inflammatory response and promotes skin wound healing in diabetes by targeting DYRK1A expression, thereby regulating the DYRK1A/STAT3 signaling pathway.
The authors present and showcase applications for an easy-to-use Python package to predict FRET efficiencies from ensembles of protein conformations via a rotamer library approach.
A Mendelian randomization study on metabolic profiling of different glycemic traits suggests hyperglycemia-independent patterns and highlights the role of insulin in the development of type 2 diabetes.
A study on long non-coding RNAs (lncRNAs) shows a lncRNA in Medicago truncatula is important for salinity tolerance. Mutants for the lncRNA show enhanced salinity tolerance through up-regulating light-harvesting chlorophyll a/b binding (MtLHCB) genes.
Noradrenergic and serotonergic signaling are involved in modulating sensory stimulation-induced astrocyte Ca2+ dynamics, and each signaling pathway alters functional hyperemia differently.
Targeted memory reactivation (TMR) facilitates inferential thinking, and applying TMR on the up-phase of the slow oscillation leads to immediate benefit in this ability, whereas the same stimulation on the down-phase leads to an immediate detriment.
The optogenetic approach sheds light on the diametric roles of ORX neurons in processing itch and pain. The neural circuit of ORX neurons from LH to the PAG region plays a crucial part in this bidirectional modulation of itch and pain processing.
HCMV induces a senescence-associated secretory phenotype (SASP)-like inflammatory response in renal but not retinal cells, potentially driving kidney pathogenesis through an IL-6-dependent senescence loop in neighboring uninfected cells.
A hyperscanning EEG study during natural unscripted dialogues shows that brain response can be predicted from the other speaker’s audio but not from oneself, even when both participants are speaking at the same time.
An fMRI study of English language comprehension suggests that cortical representations of language timescales are organized in the same way during reading and listening.
Glycosyltransferases that build bacterial surface polysaccharides were classified into 17 new CAZy families. A glycan analysis reveals that the enzymes within each family transfer similar sugars even across Gram-negative and Gram-positive bacteria.
An uncharacterized metallo-β-lactamase identified in a multidrug-resistant Chryseobacterium indologenes has an atypical lipobox and is potentially lipidated. It has a high-affinity for β-lactams including the last-resort antibiotics, carbapenems.
Evidence underscores the non-specificity of mitochondrial dye in assessing horizontal mitochondrial transfer, suggesting that alternative approaches should be considered for gaining nuanced insights into intercellular mitochondrial dynamics.