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The authors present a method utilizing the reversible protein tag ProMTag to prepare high-quality, sequencing-ready DNA and RNA, and either intact proteins or mass spectrometry-ready peptides for whole proteome analysis from a single sample.
ATLAS is a pair of AI Tumor Lineage and Site-of-origin machine learning models, that can accurately classify both primary and metastatic tumors using high-throughput RNA expression data and can identify de-differentiated anaplastic tumors.
The authors classify 293 ligand binding sites from 37 proteins into four groups by their solvent accessibility profile. The groups differ in evolutionary conservation and functional enrichment, and can be predicted by a machine learning model.
A deep learning model—OrgaSegment—is presented for segmentation of individual intestinal patient-derived organoid structures from bright-field images. This enables quantification of organoid swelling and discrimination between organoids with different levels CFTR function and response to therapy.
This study identifies postsynaptic proteins, many being kinases known to participate in ischemic injury, as major ubiquitination targets after cerebral ischemic stroke. The authors also show that ubiquitination regulates activities of these kinases.
9.4 T fMRI in marmosets shows a specialized brain network for face-voice cues processing, involving face patches and vocal areas along with parietal, prefrontal and cingulate cortices allowing complex social communication.
The intracellular effectors of bone morphogenetic protein signaling, SMAD1/5, act in skeleton-resident endothelial cells to direct bone formation in long bones of juvenile mice.
Fibroblasts actively search for and uptake microparticles from their environment and cells preferably uptake microdiamonds over latex beads. Myosin-X, EEA1 and microtubules are involved in this process.
A structural study of Asgard archaea signaling proteins identifies eukaryotic-like features that predate eukaryogenesis. However, characteristics specifying distinct eukaryotic membranes are absent, indicating these evolved during eukaryogenesis.
This study presents an image processing-based stage height control and optical trap dithering technique to detect protein-protein interactions. It was used to show that the MT binding rate for KIF5B has a strong spatial and motor length dependence.
Native MS and molecular modeling demonstrate that up to three PF4 tetramers can be assembled on a single heparin chain. Although these assemblies can accommodate only up to two antibodies, the resulting immune complexes activate platelets.
15 multi-year grassland biodiversity experiments suggest that with increasing cumulative nitrogen addition, the effect of diversity on productivity becomes increasingly reliant on a small number of dominant species rather than on overall species richness.
Wavelet analysis of mice wheel running and feeding time series unveils the impact of food restriction on dynamical patterns beyond circadian rhythms, highlighting the complex nature of mouse behavior across a spectrum of temporal scales.
Bacteriophage strain DS6A efficiently eradicates intracellular Mtb in human macrophages, while humanized mice treated with DS6A show improved pulmonary function and reduced Mtb load in mouse organs with greater efficacy in the spleen.
The authors present an adaptable ex vivo animal model to study deep tissue injury development by providing accurate quantitative data on mechanically induced cell damage in skeletal muscle tissue.
A single-agent fusion of human IL-2 and antiIL-2 antibody is discovered and engineered to selectively expand regulatory T cells and to treat autoimmune diseases.
A genome-wide association study in the China Kadoorie Biobank identified four novel loci related to snoring, and highlights the relevance of cardiometabolic health to snoring prevention.