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Analysis of 13 sediment cores from the Challenger Deep of Marian Trench (down to 11 kilometers depth) identified distinct operational taxonomic units and relevant auxiliary metabolic genes, providing further insight into deep-sea viral metabolic capabilities and ecology.
A worldwide harmonized meta-connectomic analysis of 5212 healthy young adults across 61 independent cohorts provides consistent, reproducible, and transcriptionally relevant functional connectome hubs in the resting human brain.
An integrated gene catalog of the gut microbiome in elite endurance horses is build. The holo-omics analyses identify an associative link between endurance performance and gut microbiome composition and gene function.
Rare variant association data from human genetics combined with in vitro and in vivo functional validation highlight ANGPTL7 as a promising therapeutic target for intraocular pressure reduction, and protection from glaucoma.
Cryo-EM map-guided drug design and computational comparison of ligand poses yield a PRMT5 inhibitor or derivatives that are MTA-synergic and show enhanced potency.
An investigation into the cause of death of St. Louis Individual, a 23-year old Black or African American male who died in the 1930s, reveals evidence of structural violence and the impact of systemic racism in historically marginalized communities.
Diffusion magnetic resonance imaging reveals that students’ standing in their real-world social networks is reflected in patterns of brain network connectivity.
Crystal structures of M. tuberculosis elongation factors EF-Tu and EF-Ts in complex and GDP-bound Ef-Tu reveal the molecular basis of EF-Tu’s representative recycling and inactive forms in protein translation.
Analysis of mouse oocyte epigenomics and cytoplasmic rearrangements provides insights into a developmentally important transitional phase in late oogenesis and dynamic changes of TET-enzyme mediated DNA modifications.
A freely-swimming teleost fish reproduces a previously learned distance via visual motion information, demonstrating that its visual-motion processing is dependent on visual density.
In silico and in vitro investigations reveal angular differences in the blood vessel branching points differentially alter the hemodynamics to impact endothelial structure and function.
Quaternary structure of α-synuclein fibrils characterized from human patients with Parkinson’s disease and Multiple System Atrophy modulates seeding in mouse primary oligodendroglial cultures.
A loss-of-function mutation in the RPN12a proteasome subunit in Arabidopsis thaliana shows that this protein is essential for hormonal homeostasis, thereby modulating plant’s development and the progression of leaf senescence.
SARS-CoV-2 protein expression studies in the Drosophila heart suggest a cause of COVID-19-associated cardiac pathology via interaction of virus Nsp6 with the host MGA/MAX complex disrupting glycolysis and cardiac mitochondrial function.
The crystal structure of human CEACAM1 IgV oligomer and structural analyses provide insight into higher-order oligomerization involving GFCC’ face-mediated homodimerization, flexible ABED interfaces, and dynamic metal-ion bridging.
A detailed analysis of EEG data from astronauts and other participants under extreme conditions provides insight into the neural dynamics associated with heavy mental workloads, including theta-gamma phase amplitude decoupling.
Microcosm experiments in the tropical and subtropical Atlantic reveal consistent responses of phytoplankton to changing temperature and nutrient availability, with implications for the impacts of ocean warming in oligotrophic ecosystems.
VersaLive is a versatile microfluidic platform with flexible input modes and low-volume media reservoirs that can be used for time-lapse live cell imaging, immunostaining, cell recovery, cell lysis and plasmid transfection.