Regulation of organ-organ friction in the development of morning glory petals

  • Ayaka Shimoki
  • Satoru Tsugawa
  • Seiji Takeda
Article

Advertisement

  • Mauerhofer et al. examine 80 species of methanogenic archaea at high pressures and evaluate growth and methane production, identifying Methanotorris igneus and Methanocaldococcoccus jannaschii as high-pressure methane cell factories. They find that high-performance methanogens are covered with an S-layer and harbour the amino acid motif Tyrα444 Glyα445 Tyrα446 in the alpha subunit of the methyl-coenzyme M reductase.

    • Lisa-Maria Mauerhofer
    • Sara Zwirtmayr
    • Simon K.-M. R. Rittmann
    Article Open Access
  • Jianping Li et al. present the homo-trimeric structure of the small integral membrane protein diacylglycerol kinase (DgkA) in phospholipid bilayers determined by magic angle spinning solid-state NMR spectroscopy. They compare the structure with structures solved by solution NMR and X-ray crystallography and provide insights into the influence of membrane mimetic environments on membrane proteins.

    • Jianping Li
    • Yang Shen
    • Jun Yang
    Article Open Access
  • Nam and Cheung et al. describe the structural and biochemical characterization of human autophagy factor EPG5 that functions in autophagosome–lysosome tethering. They show that hEPG5 adopts an extended shepherd’s staff architecture, binds preferentially to GABARAP proteins, and is recruited to mitochondria during mitophagy.

    • Sung-Eun Nam
    • Yiu Wing Sunny Cheung
    • Calvin K. Yip
    Article Open Access
  • Zhang et al. show that the circadian gene coupling between night feeding and day detoxification is regulated through the binding of circadian elements to E-boxes in Spodoptera litura, one of the most difficult Asian agricultural pests to control. Exposure of these larvae to a pesticide affects them more at night than during the day, suggesting the need for time-of-day considerations for pesticide application.

    • Jiwei Zhang
    • Shenglong Li
    • Kazuei Mita
    Article Open Access
  • Shimoki and Tsugawa et al. propose that the reduction in inter-organ friction is an important factor in shaping flower morphology in morning glory. Using corolla mutants, they show that defects in glandular secretory trichomes result in folding of the corolla tube and release of mechanical stress by sepal removal restores corolla elongation.

    • Ayaka Shimoki
    • Satoru Tsugawa
    • Seiji Takeda
    Article Open Access
  • Shimpei Kubota et al. describe a pipeline for quantitative whole-organ analysis that that combines tissue clearing, 3D imaging, and machine learning for analysis of the tumour microenvironment. The authors apply this in a mouse model of lung tumour and reveal the role of TGF-β in remodelling the cellular microenvironment favouring metastatic invasion.

    • Shimpei I. Kubota
    • Kei Takahashi
    • Kohei Miyazono
    Article Open Access
  • A new year symbolizes new hope for the future, especially this year as we start to see the first wave of vaccines administered against COVID-19. Here, we take stock of the year behind us and look forward to seeing where science takes us in 2021.

    Editorial Open Access
  • While loss-of-function mutations affecting the α2-Na/K ATPase are known to cause familial hemiplegic migraine, it is unclear how reduced protein activity could contribute toward migraine or paralysis observed in patients. A recent study from Sarah Smith and colleagues demonstrates that conditional deletion of the α2-Na/K ATPase in astrocytes can evoke episodic paralysis in mice, potentially due to altered metabolic processing of serine and glycine. By feeding juvenile α2-Na/K ATPase mutant mice a serine- and glycine-free diet, the authors are able to prevent the onset of episodic paralysis. This study suggests that loss of α2-Na/K ATPase in astrocytes may affect amino acid metabolism in the brain, ultimately leading to episodic paralysis.

    • George Andrew S. Inglis
    Research Highlight Open Access
  • A huge amount of intrigue surrounds the aging process. Senescence—the decreased likelihood of reproduction and the increased chance of mortality—is a hallmark of aging. The reduced ability of senescent cells to maintain protein homeostasis (proteostasis) has been well-established in nematodes but this phenomenon had yet to be directly demonstrated in human cells. Sabath et al. recently provided compelling evidence that proteostasis collapse is indeed intrinsic to human cell senescence, which may have broad implications in the underlying processes of human aging.

    • Karli Montague-Cardoso
    Research Highlight Open Access
  • Lorin Crawford began his independent career at Brown University School of Public Health with his own lab in the summer of 2017. He is currently a Senior Researcher at Microsoft Research, New England while also keeping his faculty position at Brown University. In this short Q&A he tells us about his research and the effect the pandemic has had on his lab and science. Dr. Crawford also shares some great tips on academic careers and making biostatistics approachable to wider audience and his views on the most exciting application of machine learning.

    Q&A Open Access
  • Protein aggregation and phase separation appear to play important roles in diseases like amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD), but the interplay between different participating molecular events-which may facilitate or inhibit one another-can be difficult to study by conventional ensemble methods. In a recent study, Kevin Rhine and co-workers make use of point mutations to demonstrate the contrasting behaviour of condensates arising from Glycine and Arginine FUS mutants using single molecules fluorescence measurements.

    • Krishnananda Chattopadhyay
    Research Highlight Open Access
World Cancer Day 2021

World Cancer Day 2021

In honour of World Cancer Day, a global initiative that seeks to unite the effort to fight cancer, our editors have selected some of our research highlights in cancer research from the last year to reflect on this ongoing journey. We contemplate the many emerging techniques that are furthering our understanding to improve the diagnosis, treatment and prevention processes, and look forward to another year of exciting developments.
  • Communications Biology
Collection

Nature Careers