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Pathogen spread in the puma

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  • Q&A
    | Open Access

    Lorin Crawford began his independent career at Brown University School of Public Health with his own lab in the summer of 2017. He is currently a Senior Researcher at Microsoft Research, New England while also keeping his faculty position at Brown University. In this short Q&A he tells us about his research and the effect the pandemic has had on his lab and science. Dr. Crawford also shares some great tips on academic careers and making biostatistics approachable to wider audience and his views on the most exciting application of machine learning.

  • Announcement

    Dr. Nicholas Marra is an Associate Professor at Drury University where he uses computational and sequencing approaches to understand the genetic basis of physiological adaptation in animals. Read more about his work and views on peer review at the link above!

Latest Research

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    | Open Access

    Alqassim et al find that RNA editing, known to be induced by IFN-1 in macrophages by the enzyme APOBEC3A, is required for the transcriptional, pro-inflammatory and metabolic responses that drive M1 macrophage polarization. APOBEC3A-mediated editing is also induced by IFN-1 exposure in tumor-associated macrophages isolated from ovarian cancer-related ascites fluid, pointing to a wide role for APOBEC3A in macrophages.

    • Emad Y. Alqassim
    • , Shraddha Sharma
    • , A. N. M. Nazmul H. Khan
    • , Tiffany R. Emmons
    • , Eduardo Cortes Gomez
    • , Abdulrahman Alahmari
    • , Kelly L. Singel
    • , Jaron Mark
    • , Bruce A. Davidson
    • , A. J. Robert McGray
    • , Qian Liu
    • , Brian D. Lichty
    • , Kirsten B. Moysich
    • , Jianmin Wang
    • , Kunle Odunsi
    • , Brahm H. Segal
    •  & Bora E. Baysal

  • Article
    | Open Access

    He et al. assessed different parameters of tactile processing in children diagnosed with autism spectrum disorders (ASD) and attention-deficit/hyperactivity disorder (ADHD). They found evidence for disorder-specific alterations of lower-level sensory processing, which can be related back to higher-level clinical symptoms.

    • Jason L. He
    • , Ericka Wodka
    • , Mark Tommerdahl
    • , Richard A. E. Edden
    • , Mark Mikkelsen
    • , Stewart H. Mostofsky
    •  & Nicolaas A. J. Puts

  • Article
    | Open Access

    Jeremy Gauthier et al. present the chromosome scale assembly of the genome of the parasitic wasp C. congregata and show that bracovirus genes have colonized all ten chromosomes. Comparison with genome scaffolds of another wasp reveals a striking stability of these regions over ~53 million years, suggesting strong evolutionary constraints.

    • Jérémy Gauthier
    • , Hélène Boulain
    • , Joke J. F. A. van Vugt
    • , Lyam Baudry
    • , Emma Persyn
    • , Jean-Marc Aury
    • , Benjamin Noel
    • , Anthony Bretaudeau
    • , Fabrice Legeai
    • , Sven Warris
    • , Mohamed A. Chebbi
    • , Géraldine Dubreuil
    • , Bernard Duvic
    • , Natacha Kremer
    • , Philippe Gayral
    • , Karine Musset
    • , Thibaut Josse
    • , Diane Bigot
    • , Christophe Bressac
    • , Sébastien Moreau
    • , Georges Periquet
    • , Myriam Harry
    • , Nicolas Montagné
    • , Isabelle Boulogne
    • , Mahnaz Sabeti-Azad
    • , Martine Maïbèche
    • , Thomas Chertemps
    • , Frédérique Hilliou
    • , David Siaussat
    • , Joëlle Amselem
    • , Isabelle Luyten
    • , Claire Capdevielle-Dulac
    • , Karine Labadie
    • , Bruna Laís Merlin
    • , Valérie Barbe
    • , Jetske G. de Boer
    • , Martial Marbouty
    • , Fernando Luis Cônsoli
    • , Stéphane Dupas
    • , Aurélie Hua-Van
    • , Gaelle Le Goff
    • , Annie Bézier
    • , Emmanuelle Jacquin-Joly
    • , James B. Whitfield
    • , Louise E. M. Vet
    • , Hans M. Smid
    • , Laure Kaiser
    • , Romain Koszul
    • , Elisabeth Huguet
    • , Elisabeth A. Herniou
    •  & Jean-Michel Drezen

  • Article
    | Open Access

    Rook et al. establish a viral gene transfer system to perform optogenetics in pigeons. They deliver ChR2 via AAV1 into the visual entopallium and show its behavioral relevance for contrast perception, verifying the applicability of optogenetics in an avian species.

    • Noemi Rook
    • , John Michael Tuff
    • , Sevim Isparta
    • , Olivia Andrea Masseck
    • , Stefan Herlitze
    • , Onur Güntürkün
    •  & Roland Pusch

  • Article
    | Open Access

    Anzai et al. propose a deep learning approach to estimate the 3D hemodynamics of complex aorta-coronary artery geometry in the context of coronary artery bypass surgery. Their method reduces the calculation time 600-fold, while allowing high resolution and similar accuracy as traditional computational fluid dynamics (CFD) method.

    • Gaoyang Li
    • , Haoran Wang
    • , Mingzi Zhang
    • , Simon Tupin
    • , Aike Qiao
    • , Youjun Liu
    • , Makoto Ohta
    •  & Hitomi Anzai

  • Article
    | Open Access

    Using integrative tissue-omics, Lage-Vickers, Bizzotto et al. classify prostate cancer patients into high YWHAZ and NDRG1 expression subgroups that correlate with a high and intermediate risk of disease progression. This study identifies molecular biomarkers associated with aggressive prostate cancer.

    • Sofia Lage-Vickers
    • , Juan Bizzotto
    • , Maria Pia Valacco
    • , Pablo Sanchis
    • , Sergio Nemirovsky
    • , Estefania Labanca
    • , Carlos Scorticati
    • , Osvaldo Mazza
    • , Antonina Mitrofanova
    • , Nora Navone
    • , Elba Vazquez
    • , Javier Cotignola
    •  & Geraldine Gueron
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News & Comment

  • Research Highlight
    | Open Access

    A huge amount of intrigue surrounds the aging process. Senescence—the decreased likelihood of reproduction and the increased chance of mortality—is a hallmark of aging. The reduced ability of senescent cells to maintain protein homeostasis (proteostasis) has been well-established in nematodes but this phenomenon had yet to be directly demonstrated in human cells. Sabath et al. recently provided compelling evidence that proteostasis collapse is indeed intrinsic to human cell senescence, which may have broad implications in the underlying processes of human aging.

    • Karli Montague-Cardoso

  • Q&A
    | Open Access

    Lorin Crawford began his independent career at Brown University School of Public Health with his own lab in the summer of 2017. He is currently a Senior Researcher at Microsoft Research, New England while also keeping his faculty position at Brown University. In this short Q&A he tells us about his research and the effect the pandemic has had on his lab and science. Dr. Crawford also shares some great tips on academic careers and making biostatistics approachable to wider audience and his views on the most exciting application of machine learning.

  • Research Highlight
    | Open Access

    Protein aggregation and phase separation appear to play important roles in diseases like amyotrophic lateral sclerosis (ALS) and frontotemporal lobar dementia (FTLD), but the interplay between different participating molecular events-which may facilitate or inhibit one another-can be difficult to study by conventional ensemble methods. In a recent study, Kevin Rhine and co-workers make use of point mutations to demonstrate the contrasting behaviour of condensates arising from Glycine and Arginine FUS mutants using single molecules fluorescence measurements.

    • Krishnananda Chattopadhyay

  • Editorial
    | Open Access

    Centrosomes are the main microtubule-organizing centers in animal cells, indispensable for cell division and the building of a wide range of cilia, which include sensory and motile cilia. We are now inviting submissions related to the fascinating field of centrosomes, cilia and all of the processes that they are involved in with the aim of highlighting this work in a Special Collection.

    • Tiago J. Dantas

  • Research Highlight
    | Open Access

    The CRISPR-Cas toolbox allows genetic manipulation of cultured cells, plants and animals on the basis of simpler RNA-guided DNA recognition. It has provided breakthrough scientific opportunities to engineer desirable traits, cure genetic diseases and enable point-of-care diagnostics. A recent study by Joseph Bondy-Denomy and colleagues further equips this toolbox to cut larger chunks of DNA from a cell’s genome.

    • Anam Akhtar

  • Research Highlight
    | Open Access

    It doesn’t take much to disrupt our sleep. Whilst we are aware of environmental factors that can disturb our circadian rhythms, the precise mechanisms that control molecular time cues have remained elusive. Beesley and co-workers demonstrate that diseases associated with cytoplasmic crowding affect the sleep-wake cycle. They also pinpoint a precise time-limiting step in the trafficking of the pacemaker protein PERIOD.

    • Karli Montague-Cardoso
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Collection

Mechanobiology

Marco Fritzsche

Mechanobiology

Biomechanical factors shape cellular function through influencing the structural integrity, morphology, and dynamics of cells and tissues. Here we present a collection of articles published in Communications Biology that address how mechanical forces affect biology.

Christina Karlsson Rosenthal

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