A DNA origami nanoparticle-based vaccine against SARS-Cov-2 co-delivers viral RBD antigen and CpG adjuvant and elicits a robust protective immunity against the virus in a mouse model.

This study demonstrates how proximal femoral adaptations to bipedal locomotion and lifestyles impact the risk of intracapsular hip fracture, independent of osteoporosis

A genome-wide screen of 16,471 RNAi triggers targeting SARS-CoV-2 genome by Sens.AI. identifies hyper-potent RNAi candidates against SARS-CoV-2 that are further validated in vitro and in vivo.

A genetic and lipidomic investigation reveals that depletion of ECT in Toxoplasma gondii disrupts ester-phosphatidylethanolamine (PtdEtn) synthesis and results in parasite death. Notably, T. gondii salvages ether-PtdEtn from its host cells.

Spatiotemporal spike-centered averaging (st-SCA) allows for the visualization of spike-local field potential relationships across both temporal and spatial domains from microelectrode array recordings.

A modelling framework predicts the spatial distribution of soil bacterial communities at sub-millimeter scales across varied climate conditions and soil types.

With the long-term goal of finding therapeutic options for Duchenne muscular dystrophy, a mouse model enabling simultaneous visualisation of Dmd and Utrn is described and inhibitors of PRC2 and ERK1/2 identified to increase utrophin expression.

Construction and screening of a library of all stereochemical isomers of coronatine, a mimic of the plant hormone (+)-7-iso-jasmonoyl-L-isoleucine, identify subtype-selective agonists for COI1-JAZ co-receptors in A. thaliana and S. lycopersicum.

Wastewaters have a high abundance of the bacterial species from which many mobile resistance genes emerged, as well as the genetic elements that provided mobility. This makes wastewaters plausible evolutionary arenas for such mobilization events.

A study on the effects of gene-environment interactions on body mass index (BMI) in the UK Biobank cohort finds BMI genetic loci that interact with lifestyle traits such as physical activity, smoking, and alcohol consumption.

We present a checklist to improve the reliability and reproducibility of molecular dynamics simulations and related methods.

Although we have come a long way in breaking down the stigma surrounding mental health conditions, we still have a long way to go. Here we speak to Dr Anna Schueth - a postdoc and passionate advocate whose blogs and other efforts are leading the way in changing academia towards a direction that will allow everyone to thrive as their authentic selves and to get the support they need.

Behavioral results suggest that learning by trial-and-error (i.e., reinforcement learning) relies on a teaching signal, the prediction error, which quantifies the difference between the obtained and the expected reward. Evidence suggests that distinct cortico-striatal circuits are recruited to encode better-than-expected (positive prediction error) and worst-than-expected (negative prediction error) outcomes. A recent study by Villano et al.¹ provides evidence for differential networks that underlie learning from positive and negative prediction errors in humans using real-life behavioral data. More specifically, they found that university students are more likely to update beliefs concerning grade expectations following positive rather than negative prediction errors.

A review of citation rates from genomic studies in the GWAS Catalog suggests that sharing summary statistics results, on average, in ~81.8% more citations, highlighting a benefit of publicly sharing GWAS summary statistics.

Cilia assembly and function require intraflagellar transport (IFT), a mechanism that uses “trains” to transport cargoes into and out of cilia. While much has been learned about IFT in the past decades, IFT train assembly, loading of cargo and transport regulation have remained poorly understood. In a recent study, Hesketh, Mukhopadhyay and colleagues obtained the complete structure of the IFT-A complex, a key element of IFT trains. By modelling IFT-A into anterograde trains and performing structure-guided mutagenesis, the authors uncover how the IFT-A complex polymerizes and forms carriages to accomplish its distinctive functions.

We reflect on how far we have come while looking forward to the next phase of our journey.