A review of citation rates from genomic studies in the GWAS Catalog suggests that sharing summary statistics results, on average, in ~81.8% more citations, highlighting a benefit of publicly sharing GWAS summary statistics.

Multi-omic and evolutionary analyses of the ultrasmall green algae, Medakomo hakoo, suggest that it might belong to a new genus within the class Trebouxiophyceae and provide further insight into the essential genes for microalgae.

A cell-based assay for detecting SNAP25-cleaving Botulinum neurotoxins (BoNTs) is developed by combining hiPSC-derived motor neurons and a luminescent detection system based on split NanoLuc luciferase.

A genomic investigation into strains of the plant pathogen, Xylella fastidiosa, in France indicate an American origin with two waves of invasion.

Ion channel TRPM8 mediates thermoregulatory adaptations to cold in poikilotherms by coordinating changes to skin pigmentation and locomotor activity.

A fast multidither coherent optical adaptive technology (fCOAT) focuses light through scattering tissue for optogenetic stimulation with subcellular resolution.

Angiogenic analysis and transcriptomics on bone and skeletal muscle endothelial cells from osteoarthritis patients reveal different inflammatory conditions have a different impact on these cell populations.

An integrated multi-omics analysis identifies an association chain among sleep-disordered breathing (SDB) traits, gene expression in circulating leukocytes, and serum metabolites, and supports a mechanistic role for P2XR4 purinergic signaling in SDB.

Early changes in smooth muscle cell populations in the vein wall following deep vein thrombosis in mouse may potentiate thrombus formation and venous remodeling.

Structural and mutational analyses reveal interactions between NAD⁺-glycohydrolase and Streptolysin O critical for Group A Streptococcus virulence, validated in a murine infection model.

A review of citation rates from genomic studies in the GWAS Catalog suggests that sharing summary statistics results, on average, in ~81.8% more citations, highlighting a benefit of publicly sharing GWAS summary statistics.

Cilia assembly and function require intraflagellar transport (IFT), a mechanism that uses “trains” to transport cargoes into and out of cilia. While much has been learned about IFT in the past decades, IFT train assembly, loading of cargo and transport regulation have remained poorly understood. In a recent study, Hesketh, Mukhopadhyay and colleagues obtained the complete structure of the IFT-A complex, a key element of IFT trains. By modelling IFT-A into anterograde trains and performing structure-guided mutagenesis, the authors uncover how the IFT-A complex polymerizes and forms carriages to accomplish its distinctive functions.

We reflect on how far we have come while looking forward to the next phase of our journey.

Recent structures of DNA-bound bacterial and phage recombinases provide insights into homologous recombination and suggest relation to the eukaryotic Rad52 and identification of a Rad52 single strand annealing protein (SSAP) superfamily.

The BIL1/BZR1 transcription factor is known to regulate transcriptional responses to the brassinosteroid class of phytohormones by directly recognizing short cis regulatory elements in promoters. A new study by Shohei Nosaki, Nobutaka Mitsuda, and colleagues published in Nature Plants indicates that binding of this transcription factor is additionally affected by nucleobases that influence DNA shape but are not directly contacted by BIL1/BZR1.

To commemorate LGBTQIA+ STEM Day this year, we reached out to faculty in institutional and national leadership roles to discuss their academic journeys, the importance of having queer role models and ways to better support LGQTBIA+ researchers.